Background/Aim: Intestinal damage induced by total body irradiation (TBI) reduces leucine-
rich repeat-containing G-protein-coupled receptor 5 (Lgr5)-expressing stem cells, goblet …

Oral administration (gavage) of a second-generation probiotic, Lactobacillus reuteri (L.
reuteri), that releases interleukin-22 (LR-IL-22) at 24 h after total-body irradiation (TBI) …

(1) Background: The systemic administration of therapeutic agents to the intestine including
cytokines, such as Interleukin-22 (IL-22), is compromised by damage to the …

Simple Summary The aim of our study was to assess the efficacy of a novel approach that
combines whole abdomen irradiation (WAI) with genetically engineered Limosilactobacillus …

Abdominal irradiation (IR) may destroy the intestinal mucosal barrier, leading to severe
intestinal infection and multiple organ dysfunction syndromes. The role of intestinal …

Background & Aims Treatment of inflammatory bowel disease would benefit from specific
targeting of therapeutics to the intestine. We developed a strategy for localized delivery of …

Background Recent studies have shown that gut microbiome plays important roles in
response to radiation exposure. IL-18, an inflammatory cytokine, is highly elevated in mice …

Purpose Radiation-induced gastrointestinal syndrome (RIGS) is due to the clonogenic loss
of crypt cells and villi depopulation, resulting in disruption of mucosal barrier, bacterial …

Background & Aims: The cytokines interleukin (IL)-4 and IL-13 have pleiotropic effects on a
variety of cell types and impact both pathologic changes and tissue remodeling. The aim of …

Background The small intestinal epithelium is highly sensitive to radiation and is a major site
of injury during radiation therapy and environmental overexposure. Objective To examine …