Background/Aim: Oncogene up-regulation combined with suppressor gene down-regulation
is a crucial genetic combination that promotes cell neoplastic phenotype and progressively …

In contrast to many other tumors of different lineage, oncogenic ras mutations are rarely
found within head and neck squamous cell carcinoma (HNSCC). On the other hand …

The ras gene family (H, K and N-ras) encodes the Ras protein, a GTPase-activating protein
that regulates several signal transduction pathways including cellular proliferation and …

In human tumors, somatic mutation frequently occur in K-ras gene at codon 12, which makes
the K-ras protein hyper active leading to uncontrolled signaling for cell division: one of the …

The levels of expression of the ras family genes, in 14 tumour specimens from squamous
cell carcinomas of the larynx were analysed by reverse transcription-polymerase chain …

Mutational activation and overexpression of the family of ras proto‐oncogenes have been
associated with many human tumors. The role of mutations of H‐ras, K‐ras, and N‐ras, as …

Background Nasopharyngeal carcinoma (NPC) is a highly aggressive neoplasm mainly
distributed in the eastern and southeastern parts of Asia. NPC has a poor prognosis among …

Ras genes, a class of nucleotide-binding proteins that regulate normal and transformed cell
growth, have been scarcely investigated in human brain tumours. We evaluated the …

The oncogenic function of mutant ras in mammalian cells has been extensively investigated
using multiple human and animal models. These systems include overexpression of …

Laryngeal cancer is a rare type of neoplasia, constituting approximately 2% of all human
cancers. Mutations of the ras gene family is one of the main activating mechanisms in …