Weak-evidence Fusion Candidates Detected by a FusionPlex Assay Using the Ion Torrent System
S Fujita, K Masago, E Sasaki, S Tsukushi, Y Horio… - in vivo, 2021 - iv.iiarjournals.org
Background/Aim: The Archer FusionPlex platform is widely used for comprehensive fusion-
gene detection in cancer tissues. This platform separately displays results for strong …
gene detection in cancer tissues. This platform separately displays results for strong …
The diagnostic utility of RNA-based fusion panel testing ordered by pathologists in challenging cases
Introduction Gene fusion identification by RNA-based next-generation sequencing (NGS)
provides important information for cancer patients. NGS is commonly initiated by treating …
provides important information for cancer patients. NGS is commonly initiated by treating …
108P A comprehensive pan-cancer study of fusions in Chinese cancer patients
M Li, Y Zhang, X Liang, F Lou, S Cao… - Annals of …, 2021 - annalsofoncology.org
Background Fusion represents an important type of somatic alterations which promote
oncogenesis and serve as a diagnostic and targeted marker in cancers. This study aims to …
oncogenesis and serve as a diagnostic and targeted marker in cancers. This study aims to …
Use of anchored multiplex PCR enrichment for detection of gene fusions in solid tumors by next generation sequencing
DC Green, SJ Deharvengt, FB De Abreu… - The FASEB …, 2017 - Wiley Online Library
Background The known genomic complexities of human cancer are being used to combat
the disease with novel targeted therapies. Next generation sequencing (NGS) technologies …
the disease with novel targeted therapies. Next generation sequencing (NGS) technologies …
1966P Improved sensitivity of integrative DNA and RNA NGS assay on fusion detection
J Wei, L Liu, X Chen, Q Liu, J Zhang, Y Qu… - Annals of …, 2020 - annalsofoncology.org
Background Gene fusion is an increasingly important genomic aberrant in cancer diagnosis
and treatment. Panel based RNAseq is particularly useful in detecting gene fusion since it …
and treatment. Panel based RNAseq is particularly useful in detecting gene fusion since it …
[HTML][HTML] Known and unknown gene fusion detection capabilities of solid tumour laboratories conducting next generation sequencing in 6 countries
S Finucane, S Haridas, L Handley, J Clark, A Jack… - Annals of …, 2019 - Elsevier
Background Developments in next generation sequencing (NGS) have revolutionized
oncogenic biomarker detection, removing the limitations of single-nucleotide polymorphisms …
oncogenic biomarker detection, removing the limitations of single-nucleotide polymorphisms …
Pathogenic fusion detection in solid malignancies utilizing RNA-DNA based comprehensive genomic profiling (CGP) testing.
B Piening, AK Dowdell, R Meng, A Vita… - 2022 - ascopubs.org
3078 Background: Gene fusions caused by chromosomal rearrangements comprise a key
category of oncogenic driver mutations. However, given the diverse array of potentially novel …
category of oncogenic driver mutations. However, given the diverse array of potentially novel …
Evaluating gene fusions in solid tumors–Clinical experience using an RNA based 53 gene next-generation sequencing panel
Given the known association of gene fusions with solid tumor morbidity and the need to
clarify the role of fusions in therapeutic, prognostic and diagnostic outcomes, we reviewed …
clarify the role of fusions in therapeutic, prognostic and diagnostic outcomes, we reviewed …
Comparison of four next generation sequencing platforms for fusion detection: Oncomine by ThermoFisher, AmpliSeq by illumina, FusionPlex by ArcherDX, and …
As fusion detection NGS techniques are adopted by clinical labs, assay performance
comparison is urgently needed. We compared four fusion-detection assay platforms on a …
comparison is urgently needed. We compared four fusion-detection assay platforms on a …
Targeted RNA-Capseq provides new insight into clinical fusion detection
G Jin, C Wang, X Zhang, C Yin, Q Yang, J Yang, L Wei… - Cancer Research, 2020 - AACR
Background: The precise genotyping-diagnosis of sarcomas, which is critical to clinical
treatment and management, remains challenge due to the various types and overlapping …
treatment and management, remains challenge due to the various types and overlapping …