Weak-evidence Fusion Candidates Detected by a FusionPlex Assay Using the Ion Torrent System

S Fujita, K Masago, E Sasaki, S Tsukushi, Y Horio… - in vivo, 2021 - iv.iiarjournals.org
Background/Aim: The Archer FusionPlex platform is widely used for comprehensive fusion-
gene detection in cancer tissues. This platform separately displays results for strong …

The diagnostic utility of RNA-based fusion panel testing ordered by pathologists in challenging cases

Q Wei, AC Mackinnon, GP Siegal, S Harada - Annals of Diagnostic …, 2022 - Elsevier
Introduction Gene fusion identification by RNA-based next-generation sequencing (NGS)
provides important information for cancer patients. NGS is commonly initiated by treating …

108P A comprehensive pan-cancer study of fusions in Chinese cancer patients

M Li, Y Zhang, X Liang, F Lou, S Cao… - Annals of …, 2021 - annalsofoncology.org
Background Fusion represents an important type of somatic alterations which promote
oncogenesis and serve as a diagnostic and targeted marker in cancers. This study aims to …

Use of anchored multiplex PCR enrichment for detection of gene fusions in solid tumors by next generation sequencing

DC Green, SJ Deharvengt, FB De Abreu… - The FASEB …, 2017 - Wiley Online Library
Background The known genomic complexities of human cancer are being used to combat
the disease with novel targeted therapies. Next generation sequencing (NGS) technologies …

1966P Improved sensitivity of integrative DNA and RNA NGS assay on fusion detection

J Wei, L Liu, X Chen, Q Liu, J Zhang, Y Qu… - Annals of …, 2020 - annalsofoncology.org
Background Gene fusion is an increasingly important genomic aberrant in cancer diagnosis
and treatment. Panel based RNAseq is particularly useful in detecting gene fusion since it …

[HTML][HTML] Known and unknown gene fusion detection capabilities of solid tumour laboratories conducting next generation sequencing in 6 countries

S Finucane, S Haridas, L Handley, J Clark, A Jack… - Annals of …, 2019 - Elsevier
Background Developments in next generation sequencing (NGS) have revolutionized
oncogenic biomarker detection, removing the limitations of single-nucleotide polymorphisms …

Pathogenic fusion detection in solid malignancies utilizing RNA-DNA based comprehensive genomic profiling (CGP) testing.

B Piening, AK Dowdell, R Meng, A Vita… - 2022 - ascopubs.org
3078 Background: Gene fusions caused by chromosomal rearrangements comprise a key
category of oncogenic driver mutations. However, given the diverse array of potentially novel …

Evaluating gene fusions in solid tumors–Clinical experience using an RNA based 53 gene next-generation sequencing panel

P Selvam, K Kelly, AN Hesse, D Spitzer, HV Reddi - Cancer Genetics, 2019 - Elsevier
Given the known association of gene fusions with solid tumor morbidity and the need to
clarify the role of fusions in therapeutic, prognostic and diagnostic outcomes, we reviewed …

Comparison of four next generation sequencing platforms for fusion detection: Oncomine by ThermoFisher, AmpliSeq by illumina, FusionPlex by ArcherDX, and …

X Qu, C Yeung, I Coleman, PS Nelson, M Fang - Cancer genetics, 2020 - Elsevier
As fusion detection NGS techniques are adopted by clinical labs, assay performance
comparison is urgently needed. We compared four fusion-detection assay platforms on a …

Targeted RNA-Capseq provides new insight into clinical fusion detection

G Jin, C Wang, X Zhang, C Yin, Q Yang, J Yang, L Wei… - Cancer Research, 2020 - AACR
Background: The precise genotyping-diagnosis of sarcomas, which is critical to clinical
treatment and management, remains challenge due to the various types and overlapping …