In vivo absorption of didanosine formulated in pellets composed of chitosan microspheres
The in vivo absorption of didanosine was studied, focusing on the performance of a novel
pharmaceutical formulation for didanosine, composed of chitosan granules containing …
pharmaceutical formulation for didanosine, composed of chitosan granules containing …
[HTML][HTML] Preparation of gastro-resistant pellets containing chitosan microspheres for improvement of oral didanosine bioavailability
P Severino, GGG de Oliveira, HG Ferraz… - Journal of …, 2012 - Elsevier
The purpose of this work was to introduce a new concept of coated pellets containing
chitosan microspheres loaded with didadosine for oral administration, aiming at reducing …
chitosan microspheres loaded with didadosine for oral administration, aiming at reducing …
The intestinal permeation of didanosine from granules containing microspheres using the everted gut sac model
The aim of this research is to evaluate the intestinal permeation of a new formulation (NF) for
the anti-retroviral didanosine (ddI) drug, using the everted gut sac model. The NF is …
the anti-retroviral didanosine (ddI) drug, using the everted gut sac model. The NF is …
Didanosine-loaded chitosan microspheres optimized by surface-response methodology: A modified “Maximum Likelihood Classification” approach formulation for …
Didanosine-loaded chitosan microspheres were developed applying a surface-response
methodology and using a modified Maximum Likelihood Classification. The operational …
methodology and using a modified Maximum Likelihood Classification. The operational …
Bioequivalence of two formulations of didanosine, encapsulated enteric‐coated beads and buffered tablet, in healthy volunteers and HIV‐infected subjects
BD Damle, S Kaul, D Behr… - The Journal of Clinical …, 2002 - Wiley Online Library
Didanosine is an acid labile drug and hence has been given with buffering agents. To avoid
the need for concurrent administration with antacids, an encapsulated enteric‐coated bead …
the need for concurrent administration with antacids, an encapsulated enteric‐coated bead …
Mannan-coated gelatin nanoparticles for sustained and targeted delivery of didanosine: in vitro and in vivo evaluation
Sažetak Macrophages of the reticuloendothelial system and brain act as major reservoir for
HIV because of their long term survival after HIV infection and ability to spread virus particles …
HIV because of their long term survival after HIV infection and ability to spread virus particles …
Single-dose pharmacokinetics of enteric-coated didanosine in HIV-infected children
JR King, S Nachman, R Yogev, J Hodge… - Antiviral …, 2002 - journals.sagepub.com
Didanosine remains a cornerstone nucleoside analogue for the treatment of HIV infection. A
potential problem with the buffered formulations of didanosine is the likelihood of …
potential problem with the buffered formulations of didanosine is the likelihood of …
Intranasal drug delivery of didanosine-loaded chitosan nanoparticles for brain targeting; an attractive route against infections caused by AIDS viruses
AM Al-Ghananeem, H Saeed, R Florence… - Journal of drug …, 2010 - Taylor & Francis
The primary aim of this study was to investigate intranasal (in) administration as a potential
route to enhance systemic and brain delivery of didanosine (ddI). A further aim was to …
route to enhance systemic and brain delivery of didanosine (ddI). A further aim was to …
Role of chitosan nanoparticles in the oral absorption of Gemcitabine
K Derakhshandeh, S Fathi - International journal of pharmaceutics, 2012 - Elsevier
Gemcitabine is a known cytotoxic agent with a wide spectrum of antitumor activity. It has
been employed in therapeutic regimens for various malignancies such as the lung, ovary …
been employed in therapeutic regimens for various malignancies such as the lung, ovary …
Delivery of didanosine from enteric-coated, sustained-release bioadhesive formulation
D Deshmukh, WR Ravis, GV Betageri - Drug delivery, 2003 - Taylor & Francis
The aim of our study is to assess the release characteristics, in vitro permeation, and stability
of an enteric-coated, bioadhesive, sustained-release formulation of didanosine (ddI). Enteric …
of an enteric-coated, bioadhesive, sustained-release formulation of didanosine (ddI). Enteric …