In vivo absorption of didanosine formulated in pellets composed of chitosan microspheres

P Severino, CF Da Silva, TCT Dalla Costa, H Silva… - in vivo, 2014 - iv.iiarjournals.org
The in vivo absorption of didanosine was studied, focusing on the performance of a novel
pharmaceutical formulation for didanosine, composed of chitosan granules containing …

[HTML][HTML] Preparation of gastro-resistant pellets containing chitosan microspheres for improvement of oral didanosine bioavailability

P Severino, GGG de Oliveira, HG Ferraz… - Journal of …, 2012 - Elsevier
The purpose of this work was to introduce a new concept of coated pellets containing
chitosan microspheres loaded with didadosine for oral administration, aiming at reducing …

The intestinal permeation of didanosine from granules containing microspheres using the everted gut sac model

CF da Silva, P Severino, F Martins… - Journal of …, 2009 - Taylor & Francis
The aim of this research is to evaluate the intestinal permeation of a new formulation (NF) for
the anti-retroviral didanosine (ddI) drug, using the everted gut sac model. The NF is …

Didanosine-loaded chitosan microspheres optimized by surface-response methodology: A modified “Maximum Likelihood Classification” approach formulation for …

CF da Silva, P Severino, F Martins… - Biomedicine & …, 2015 - Elsevier
Didanosine-loaded chitosan microspheres were developed applying a surface-response
methodology and using a modified Maximum Likelihood Classification. The operational …

Bioequivalence of two formulations of didanosine, encapsulated enteric‐coated beads and buffered tablet, in healthy volunteers and HIV‐infected subjects

BD Damle, S Kaul, D Behr… - The Journal of Clinical …, 2002 - Wiley Online Library
Didanosine is an acid labile drug and hence has been given with buffering agents. To avoid
the need for concurrent administration with antacids, an encapsulated enteric‐coated bead …

Mannan-coated gelatin nanoparticles for sustained and targeted delivery of didanosine: in vitro and in vivo evaluation

A Kaur, S Jain, AK Tiwary - Acta pharmaceutica, 2008 - hrcak.srce.hr
Sažetak Macrophages of the reticuloendothelial system and brain act as major reservoir for
HIV because of their long term survival after HIV infection and ability to spread virus particles …

Single-dose pharmacokinetics of enteric-coated didanosine in HIV-infected children

JR King, S Nachman, R Yogev, J Hodge… - Antiviral …, 2002 - journals.sagepub.com
Didanosine remains a cornerstone nucleoside analogue for the treatment of HIV infection. A
potential problem with the buffered formulations of didanosine is the likelihood of …

Intranasal drug delivery of didanosine-loaded chitosan nanoparticles for brain targeting; an attractive route against infections caused by AIDS viruses

AM Al-Ghananeem, H Saeed, R Florence… - Journal of drug …, 2010 - Taylor & Francis
The primary aim of this study was to investigate intranasal (in) administration as a potential
route to enhance systemic and brain delivery of didanosine (ddI). A further aim was to …

Role of chitosan nanoparticles in the oral absorption of Gemcitabine

K Derakhshandeh, S Fathi - International journal of pharmaceutics, 2012 - Elsevier
Gemcitabine is a known cytotoxic agent with a wide spectrum of antitumor activity. It has
been employed in therapeutic regimens for various malignancies such as the lung, ovary …

Delivery of didanosine from enteric-coated, sustained-release bioadhesive formulation

D Deshmukh, WR Ravis, GV Betageri - Drug delivery, 2003 - Taylor & Francis
The aim of our study is to assess the release characteristics, in vitro permeation, and stability
of an enteric-coated, bioadhesive, sustained-release formulation of didanosine (ddI). Enteric …