Amentoflavone inhibits ERK-modulated tumor progression in hepatocellular carcinoma in vitro

KC Lee, JJ Tsai, CW Tseng, YC Kuo, YC Chuang… - in vivo, 2018 - iv.iiarjournals.org
Background/Aim: A previous study indicated that amentoflavone inhibits tumor growth of
breast cancer. However, the anti-cancer effects and mechanism of amentoflavone in …

Amentoflavone inhibits hepatocellular carcinoma progression through blockage of ERK/NF-ĸB activation

KC Lee, WT Chen, YC Liu, SS Lin, FT Hsu - in vivo, 2018 - iv.iiarjournals.org
Aim: The aim of the present study was to confirm therapeutic efficacy and find probable
mechanism of action of amentoflavone in hepatocellular carcinoma (HCC) in vivo. Materials …

Amentoflavone enhances the therapeutic efficacy of sorafenib by inhibiting anti-apoptotic potential and potentiating apoptosis in hepatocellular carcinoma in vivo

JJ Tsai, FT Hsu, PJ Pan, CW Chen… - Anticancer research, 2018 - ar.iiarjournals.org
Background/Aim: In a previous study, we showed that amentoflavone promotes sorafenib-
induced apoptosis in hepatocellular carcinoma (HCC) cells in vitro. However, whether …

Amentoflavone induces cell-cycle arrest, apoptosis, and invasion inhibition in non-small cell lung cancer cells

WT Chen, CH Chen, HT Su, PF Yueh, FT Hsu… - Anticancer …, 2021 - ar.iiarjournals.org
Background/Aim: Amentoflavone, an effective compound derived from medicinal plants, has
been shown to boost therapeutic efficacy of chemotherapy in non-small cell lung cancer …

[HTML][HTML] Amentoflavone enhances sorafenib‑induced apoptosis through extrinsic and intrinsic pathways in sorafenib‑resistant hepatocellular carcinoma SK‑Hep1 cells …

WL Chen, CL Hsieh, JH Chen… - Oncology …, 2017 - spandidos-publications.com
The present study aimed to evaluate the effects of amentoflavone on sorafenib‑induced
apoptosis in sorafenib‑resistant hepatocellular carcinoma (HCC) cells. The sorafenib …

Amentoflavone inhibits metastatic potential through suppression of ERK/NF-κB activation in osteosarcoma U2OS cells

PJ Pan, JJ Tsai, YC Liu - Anticancer Research, 2017 - ar.iiarjournals.org
Aim: The study goal was to investigate effect of amentoflavone on nuclear factor-κB (NF-κB)-
modulated metastatic mechanism in osteosarcoma U2OS cells. U2OS cells were treated …

Suppression of ERK/NF-κB activation is associated with amentoflavone-inhibited osteosarcoma progression in vivo

YJ Lee, JG Chung, YT Chien, SS Lin… - Anticancer research, 2019 - ar.iiarjournals.org
Background/Aim: Amentoflavone has been implicated in reducing the metastatic potential of
osteosarcoma (OS) cells in vitro. The aim of the present study was to verify the antitumoral …

Amentoflavone Effectively Blocked the Tumor Progression of Glioblastoma via Suppression of ERK/NF-B Signaling Pathway

FT Hsu, IT Chiang, YC Kuo, TC Hsia… - The American journal …, 2019 - World Scientific
Glioblastoma is the most common primary malignant tumor of the central nervous system,
with an annual incidence of 5.26 per 100000 people. The clinical outcome of standard …

Inactivation of AKT/ERK signaling and induction of apoptosis are associated with amentoflavone sensitization of hepatocellular carcinoma to lenvatinib

CJ Yang, MH Wu, JJ Tsai, FT Hsu, TC Hsia… - Anticancer …, 2022 - ar.iiarjournals.org
Background/Aim: AKT/ERK signaling transduction and anti-apoptosis effects have both been
recognized as important mediators of hepatocellular carcinoma (HCC) progression …

Amentoflavone induces anti-angiogenic and anti-metastatic effects through suppression of NF-κB activation in MCF-7 cells

JH Chen, WL Chen, YC Liu - Anticancer Research, 2015 - ar.iiarjournals.org
The aim of the present study was to investigate whether amentoflavone induces anti-
angiogenic and anti-metastatic effects through suppression of NF-κB activation in breast …