Apoptotic markers p53, Bcl-2 and Bax in primary lung cancer

I PORĘBSKA, E Wyrodek, M Kosacka, J Adamiak… - In vivo, 2006 - iv.iiarjournals.org
Background: Apoptosis is the fundamental process necessary for eliminating damaged or
unwanted cells. Alterations in the apoptotic pathway appear to be key events in cancer …

Prognostic value of immunohistochemical expression of p53, bax, Bcl‐2 and Bcl‐xL in resected non‐small‐cell lung cancers

AM Groeger, V Esposito, A De Luca… - …, 2004 - Wiley Online Library
Aims: Some experimental evidence suggests that in lung cancer, development, progression
and an increased proliferation rate can be linked to apoptosis‐related factors. In this study …

Expression of p53 protein and the apoptotic regulatory molecules Bcl-2, Bcl-XL, and Bax in locally advanced squamous cell carcinoma of the lung

MS Shabnam, R Srinivasan, A Wali, S Majumdar… - Lung cancer, 2004 - Elsevier
Objective: Bcl-2 family of proteins plays a critical role in the regulation of apoptosis. This
pathway may be dysregulated leading to an altered ratio of pro-and anti-apoptotic …

Expression of Bcl-2, Bax, and p53 proteins in carcinogenesis of squamous cell lung cancer.

Y Chen, M Sato, S Fujimura, C Endo… - Anticancer …, 1999 - europepmc.org
Background Apoptosis is regulated by many genes, including bcl-2, p53, and bcl-2 family
genes. The expression of Bcl-2, p53, and Bax in very early lung cancers or precancer …

Bcl-2 protein expression correlates with better prognosis in patients with advanced non-small cell lung cancer

Y Shibata, S Hidaka, Y Tagawa… - Anticancer research, 2004 - ar.iiarjournals.org
Background: Regulation of apoptosis is an important mechanism during the development of
tumors including non-small cell lung cancer (NSCLC). The aim of this study was to assess …

Immunohistochemical demonstration of apoptosis-regulated proteins, Bcl-2 and Bax, in resected non-small-cell lung cancers

T Hanaoka, J Nakayama, M Haniuda… - International Journal of …, 2002 - Springer
Abstract Objective. Bcl-2 and Bax proteins regulate apoptosis independently, cooperatively,
or both in vitro. The purpose of this study was to clarify the association between their …

p53 and Bcl-2 protein expression and its relationship with prognosis in small-cell lung cancer

M Zereu, JJF Vinholes, CG Zettler - Clinical Lung Cancer, 2003 - Elsevier
Small-cell lung cancer (SCLC) has a poor prognosis despite good initial response to
chemotherapy. Therefore, it is important to identify molecular markers that might influence …

Prognostic value of the expression of p53, bcl-2, and bax oncoproteins, and neovascularization in patients with radically resected non-small-cell lung cancer.

RM Apolinario, P van der Valk, JS de Jong… - Journal of clinical …, 1997 - ascopubs.org
PURPOSE To assess the prognostic value of p53, bcl-2, bax, and neovascularization in
radically resected non-small-cell lung cancer (NSCLC) patients. PATIENTS AND METHODS …

Frequent high expression of bax pro-apoptotic protein in non-small cell lung cancer.

M Caputi, AM Groeger, V Esposito, A De Luca… - Anticancer …, 1999 - europepmc.org
Bax, bcl-2 and their homologues regulate a distal step in an evolutionary very well
conserved pathway of apoptotic cell death. It plays a crucial role in the balance between …

Expression of apoptosis regulatory proteins of the Bcl-2 family and p53 in primary resected non-small-cell lung cancer

MM Borner, P Brousset, B Pfanner-Meyer… - British journal of …, 1999 - nature.com
Proteins of the Bcl-2 family as well as p53 are important regulators of apoptosis. Alterations
in the expression of these proteins can contribute to the formation of cancer, as well as …