Alteration of inflammatory cytokine production in the injured central nervous system of tenascin-deficient mice

H Ikeshima-Kataoka, JS Shen, Y Eto, S Saito, S Yuasa - in vivo, 2008 - iv.iiarjournals.org
Although tenascin-C (TN) is highly up-regulated during the proliferation of reactive
astrocytes, little is known about the function of TN at injury sites in the central nervous …

[HTML][HTML] Different functions of recombinantly expressed domains of Tenascin-C in glial scar formation

D Bijelić, M Adžić, M Perić, I Jakovčevski… - Frontiers in …, 2021 - frontiersin.org
Extracellular matrix glycoprotein tenascin-C (TnC) is highly expressed in vertebrates during
embryonic development and thereafter transiently in tissue niches undergoing extensive …

Tenascin-C regulates proliferation and migration of cultured astrocytes in a scratch wound assay

T Nishio, S Kawaguchi, M Yamamoto, T Iseda… - Neuroscience, 2005 - Elsevier
Tenascin-C (TNC), an extracellular matrix glycoprotein, is involved in tissue morphogenesis
like embryogenesis, wound healing or tumorigenesis. Astrocytes are known to play major …

[HTML][HTML] Tenascin-C restricts reactive astrogliosis in the ischemic brain

E Dzyubenko, D Manrique-Castano, M Pillath-Eilers… - Matrix Biology, 2022 - Elsevier
Cellular responses in glia play a key role in regulating brain remodeling post-stroke.
However, excessive glial reactivity impedes post-ischemic neuroplasticity and hampers …

Macrophage/microglia regulation of astrocytic tenascin: synergistic action of transforming growth factor-β and basic fibroblast growth factor

GM Smith, JH Hale - Journal of Neuroscience, 1997 - Soc Neuroscience
After injury to the CNS, extracellular matrix molecules such as tenascin are upregulated
around the injury site and may be involved in inhibition of axon growth. In the present study …

[HTML][HTML] Tenascin-C preserves microglia surveillance and restricts leukocyte and, more specifically, T cell infiltration of the ischemic brain

D Manrique-Castano, E Dzyubenko, M Borbor… - Brain, Behavior, and …, 2021 - Elsevier
As an endogenous activator of toll-like receptor-4 (Tlr4), the extracellular matrix glycoprotein
tenascin-C (TnC) regulates chemotaxis, phagocytosis and proinflammatory cytokine …

Tenascin-R is antiadhesive for activated microglia that induce downregulation of the protein after peripheral nerve injury: a new role in neuronal protection

DN Angelov, M Walther, M Streppel… - Journal of …, 1998 - Soc Neuroscience
Microglial activation in response to pathological stimuli is characterized by increased
migratory activity and potential cytotoxic action on injured neurons during later stages of …

Deficiency of tenascin-C alleviates neuronal apoptosis and neuroinflammation after experimental subarachnoid hemorrhage in mice

L Liu, M Fujimoto, F Nakano, H Nishikawa… - Molecular …, 2018 - Springer
Abstract Tenascin-C (TNC), a matricellular protein, is upregulated in brain parenchyma after
experimental subarachnoid hemorrhage (SAH). Recent studies emphasize that early brain …

[HTML][HTML] Tenascin-R plays a role in neuroprotection via its distinct domains that coordinate to modulate the microglia function

H Liao, W Bu, TH Wang, S Ahmed, ZC Xiao - Journal of Biological …, 2005 - ASBMB
Microglia are one of the main cell types activated by brain injury. In the present study, we
have investigated how domains of the extracellular matrix molecule tenascin-R (TN-R) …

Analysis of combinatorial variability reveals selective accumulation of the fibronectin type III domains B and D of tenascin-C in injured brain

A Dobbertin, S Czvitkovich, U Theocharidis… - Experimental …, 2010 - Elsevier
Tenascin-C (Tnc) is a multimodular extracellular matrix glycoprotein that is markedly
upregulated in CNS injuries where it is primarily secreted by reactive astrocytes. Different …