Background/Aim: Bacterial resistance to antibiotics has become a serious problem in
antibacterial chemotherapy and resistance of bacteria to chemically-unrelated anti-microbial …

Background: Because phenothiazines inhibit efflux pumps of bacteria, forty new
phenothiazine derivatives were tested for their inhibition of the efflux pump systems of Gram …

In this study, we tested five compounds belonging to a novel series of piperazine
arylideneimidazolones for the ability to inhibit the AcrAB-TolC efflux pump. The …

There is an urgent need to find novel treatments for combating multidrug-resistant bacteria.
Multidrug efflux pumps that expel antibiotics out of cells are major contributors to this …

Efflux pump inhibitors (EPIs) are attractive compounds to reverse multidrug-resistance in
clinically relevant bacterial pathogens. In this study we tested the ability of the neuroleptic …

Multidrug resistant (MDR) bacteria are an increasing health problem with the shortage of
new active antibiotic agents. Among effective mechanisms that contribute to the spread of …

Overexpression of efflux pumps extruding antibiotics currently used for the treatment of
Acinetobacter baumannii infections has been described as an important mechanism …

Background: Hydantoin derivatives have important biochemical and pharmacological
properties. In the present study, 23 hydantoin compounds were evaluated for their efflux …

The anti-microbial activity of six non-antibiotics (one amino-ethylchloride, three
phenothiazines, two tricyclic antidepressives) were tested on 20 clinical isolates of …

Members of the resistance-nodulation-division (RND) family of efflux pumps, such as AcrAB-
TolC of Escherichia coli, play major roles in multidrug resistance (MDR) in Gram-negative …