Recovery of liver sinusoidal endothelial cells following monocrotaline-induced liver injury

F Otaka, Y Ito, T Goto, K Kojo, M Tanabe, K Hosono… - in vivo, 2021 - iv.iiarjournals.org
Background/Aim: Although the pathology of sinusoidal obstruction syndrome (SOS) is
characterized by damage to liver sinusoidal endothelial cells (LSECs), the processes …

The role of liver sinusoidal endothelial cells in liver remodeling after injury

ZW Li, L Wang - Hepatobiliary & Pancreatic Diseases International, 2023 - Elsevier
Liver transplantation is the optimal treatment for patients with end-stage liver disease,
metabolic liver diseases, and hepatic malignancies that are not amenable to resection …

Soluble thrombomodulin attenuates endothelial cell damage in hepatic sinusoidal obstruction syndrome

S Takada, T Miyashita, Y Yamamoto, S Kanou… - in vivo, 2018 - iv.iiarjournals.org
Background: Hepatic sinusoidal obstruction syndrome (SOS), also known as veno-occlusive
disease, is a form of drug-induced liver injury, the initial morphological changes associated …

[HTML][HTML] Treprostinil reduces endothelial damage in murine sinusoidal obstruction syndrome

M Themanns, F Koban, C Bergmayr, A Chrzan… - Journal of Molecular …, 2019 - Springer
Sinusoidal obstruction syndrome (SOS) is a major complication after hematopoietic stem cell
transplantation and belongs to a group of diseases increasingly identified as transplant …

[HTML][HTML] Platelets prevent the development of monocrotaline-induced liver injury in mice

F Otaka, Y Ito, T Goto, K Eshima, H Amano, W Koizumi… - Toxicology Letters, 2020 - Elsevier
Destruction of liver sinusoidal endothelial cells (LSECs) is an initial event in sinusoidal
obstruction syndrome (SOS) that leads to accumulation of platelets in the liver. Herein, we …

Lineage tracing reveals conversion of liver sinusoidal endothelial cells into hepatocytes

Z Tan, K Chen, Y Shao, L Gao, Y Wang… - Development …, 2016 - Wiley Online Library
Although liver sinusoidal endothelial cells (LSEC s) have long been known to contribute to
liver regeneration following injury, the exact role of these cells in liver regeneration remains …

Role of liver sinusoidal endothelial cells in liver regeneration and the development of liver fibrosis

Y ZiYue, L Xin, C LiNa - 临床肝胆病杂志, 2019 - lcgdbzz.org
As a main population of liver nonparenchymal cells, liver sinusoidal endothelial cells
(LSECs) are thin-layer flattened cells lining the hepatic sinusoid, and the fenestrae on the …

Bone marrow progenitor cells repair rat hepatic sinusoidal endothelial cells after liver injury

R Harb, G Xie, C Lutzko, Y Guo, X Wang, CK Hill… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: Damage to hepatic sinusoidal endothelial cells (SECs) initiates
sinusoidal obstruction syndrome (SOS), which is most commonly a consequence of …

[HTML][HTML] Targeting endothelial Erk1/2-Akt axis as a regeneration strategy to bypass fibrosis during chronic liver injury in mice

Y Lao, Y Li, P Zhang, Q Shao, W Lin, B Qiu, Y Lv… - Molecular Therapy, 2018 - cell.com
Liver sinusoidal endothelial cells (LSECs) have great capacity for liver regeneration, and
this capacity can easily switch to profibrotic phenotype, which is still poorly understood. In …

Role of liver sinusoidal endothelial cells in liver diseases

J Gracia-Sancho, E Caparrós… - Nature reviews …, 2021 - nature.com
Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike
other capillaries, they lack an organized basement membrane and have cytoplasm that is …