Abstract Background/Aim: Meningiomas represent the main intracranial primary central
nervous system (CNS) tumour in adults worldwide. Oncogenes' over-activation combined …

Meningiomas are generally benign, but some meningiomas show malignancy with invasion
and high recurrence rates. We investigated whether alterations in p53 protein may …

Overexpression of p53 has been reported to play a role in the development of neoplasms of
the central nervous system. Meningiomas are generally benign intracranial tumors …

Formalin-fixed, paraffin-embedded surgical specimens from 55 meningiomas were
immunostained with monoclonal antibody against p53 (Immunotech, Marseilles, France) …

Prediction of recurrence after resection of benign meningiomas represents a significant
clinical problem. A prospective study commenced in 1984 aimed to elucidate the molecular …

Association of p53 gene abnormalities with tumor progression and prognosis of many
neoplasms has been demonstrated, but little is known about the clinical significance of p53 …

Evaluation of the p53 gene protein expression and proliferative potential with MIB-1
monoclonal antibody (MBL Co.), a new marker of cellular proliferation that binds Ki67 in …

Meningiomas, one of the largest subgroup of intracranial tumours are generally benign, but
can progress to malignancy. They are classified into the three World Health Organization …

The aim of the present study was to identify TP53 exon 4 mutations in patients with
meningioma and to investigate their potential association with specific tumor pathology …

Background and Objective: Histological grading has prognostic and therapeutic implications
in meningioma. However, histological criteria are sometimes not fulfilled to predict the …