Improved longevity of hematopoiesis in long-term bone marrow cultures and reduced irradiation-induced pulmonary fibrosis in Toll-like receptor-4 deletion …

BH Rhieu, MW Epperly, S Cao, J Goff, D Shields… - in vivo, 2014 - iv.iiarjournals.org
Aim: We measured long-term hematopoiesis in continuous bone marrow cultures derived
from Toll-like receptor-4 (Tlr4−/−)(C57BL/6J) mice. Materials and Methods: We measured …

Reduced radiation pulmonary fibrosis in toll-like receptor-4 (TLR4) deletion recombinant negative mice

M Epperly, B Rhieu, S Cao, J Goff, D Shields… - International Journal of …, 2014 - redjournal.org
Results Homozygous deletion of TLR4 resulted in improvement of multiple parameters of
hematopoiesis in LTBMC including: Increased formation of cobblestone islands from week 1 …

Toll-like receptor 4 protects against irradiation-induced hematopoietic injury by promoting granulopoiesis and alleviating marrow adipogenesis

Z Sun, K Wu, Q Lin, H Fei, H Jiang, T Chen… - Biochemical and …, 2019 - Elsevier
Irradiation induces severe damage in the hematopoietic system, which leads to bone
marrow hyperplasia, pancytopenia, and aggravated tissue formation in bone marrow …

Combined Tlr2 and Tlr4 deficiency increases radiation-induced pulmonary fibrosis in mice

A Paun, J Fox, V Balloy, M Chignard, ST Qureshi… - International Journal of …, 2010 - Elsevier
PURPOSE: To determine whether Toll-like receptor 2 or 4 genotype alters the lung response
to irradiation in C57BL/6 mice using a model developing a phenotype that resembles …

Apoptosis resistance in fibroblasts precedes progressive scarring in pulmonary fibrosis and is partially mediated by toll-like receptor 4 activation

KM Hanson, EB Hernady, CK Reed… - Toxicological …, 2019 - academic.oup.com
Inhalation of environmental toxicants such as cigarette smoke, metal or wood dust, silica, or
asbestos is associated with increased risk for idiopathic pulmonary fibrosis (IPF). IPF …

TLR5 signaling in murine bone marrow induces hematopoietic progenitor cell proliferation and aids survival from radiation

B Zhang, D Oyewole-Said, J Zou, IR Willliams… - Blood …, 2017 - ashpublications.org
Administration of the bacterial protein flagellin to mice activates innate immune signaling
that protects against an array of challenges, including ionizing radiation. Herein, we define …

[HTML][HTML] Systemic TLR2 agonist exposure regulates hematopoietic stem cells via cell-autonomous and cell-non-autonomous mechanisms

AC Herman, DA Monlish, MP Romine, ST Bhatt… - Blood cancer …, 2016 - nature.com
Abstract Toll-like receptor 2 (TLR2) is a member of the TLR family of receptors that play a
central role in innate immunity. In addition to regulating effector immune cells, where it …

Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin

L Janot, JC Sirard, T Secher, N Noulin… - European journal of …, 2009 - Wiley Online Library
Bacterial products (such as endotoxins and flagellin) trigger innate immune responses
through TLRs. Flagellin‐induced signalling involves TLR5 and MyD88 and, according to …

[HTML][HTML] A critical role of toll-like receptor 4 (TLR4) and its' in vivo ligands in basal radio-resistance

C Liu, C Zhang, REJ Mitchel, J Cui, J Lin, Y Yang… - Cell death & …, 2013 - nature.com
Abstract Toll-like receptor-4 (TLR4) plays a critical role in innate and acquired immunity, but
its role in radio-resistance is unknown. We used TLR4 knockout (KO,−/−) mice and gut …

Toll-like receptor 2-deficiency on bone marrow-derived cells augments vascular healing of murine arterial lesions

W Liu, JC Eczko, M Otto, R Bajorat, B Vollmar… - Life sciences, 2020 - Elsevier
Aims Neointimal hyperplasia contributes to arterial restenosis after percutaneous
transluminal coronary angioplasty or vascular surgery. Neointimal thickening after arterial …