Improved longevity of hematopoiesis in long-term bone marrow cultures and reduced irradiation-induced pulmonary fibrosis in Toll-like receptor-4 deletion …
BH Rhieu, MW Epperly, S Cao, J Goff, D Shields… - in vivo, 2014 - iv.iiarjournals.org
Aim: We measured long-term hematopoiesis in continuous bone marrow cultures derived
from Toll-like receptor-4 (Tlr4−/−)(C57BL/6J) mice. Materials and Methods: We measured …
from Toll-like receptor-4 (Tlr4−/−)(C57BL/6J) mice. Materials and Methods: We measured …
Reduced radiation pulmonary fibrosis in toll-like receptor-4 (TLR4) deletion recombinant negative mice
M Epperly, B Rhieu, S Cao, J Goff, D Shields… - International Journal of …, 2014 - redjournal.org
Results Homozygous deletion of TLR4 resulted in improvement of multiple parameters of
hematopoiesis in LTBMC including: Increased formation of cobblestone islands from week 1 …
hematopoiesis in LTBMC including: Increased formation of cobblestone islands from week 1 …
Toll-like receptor 4 protects against irradiation-induced hematopoietic injury by promoting granulopoiesis and alleviating marrow adipogenesis
Z Sun, K Wu, Q Lin, H Fei, H Jiang, T Chen… - Biochemical and …, 2019 - Elsevier
Irradiation induces severe damage in the hematopoietic system, which leads to bone
marrow hyperplasia, pancytopenia, and aggravated tissue formation in bone marrow …
marrow hyperplasia, pancytopenia, and aggravated tissue formation in bone marrow …
Combined Tlr2 and Tlr4 deficiency increases radiation-induced pulmonary fibrosis in mice
A Paun, J Fox, V Balloy, M Chignard, ST Qureshi… - International Journal of …, 2010 - Elsevier
PURPOSE: To determine whether Toll-like receptor 2 or 4 genotype alters the lung response
to irradiation in C57BL/6 mice using a model developing a phenotype that resembles …
to irradiation in C57BL/6 mice using a model developing a phenotype that resembles …
Apoptosis resistance in fibroblasts precedes progressive scarring in pulmonary fibrosis and is partially mediated by toll-like receptor 4 activation
KM Hanson, EB Hernady, CK Reed… - Toxicological …, 2019 - academic.oup.com
Inhalation of environmental toxicants such as cigarette smoke, metal or wood dust, silica, or
asbestos is associated with increased risk for idiopathic pulmonary fibrosis (IPF). IPF …
asbestos is associated with increased risk for idiopathic pulmonary fibrosis (IPF). IPF …
TLR5 signaling in murine bone marrow induces hematopoietic progenitor cell proliferation and aids survival from radiation
Administration of the bacterial protein flagellin to mice activates innate immune signaling
that protects against an array of challenges, including ionizing radiation. Herein, we define …
that protects against an array of challenges, including ionizing radiation. Herein, we define …
[HTML][HTML] Systemic TLR2 agonist exposure regulates hematopoietic stem cells via cell-autonomous and cell-non-autonomous mechanisms
AC Herman, DA Monlish, MP Romine, ST Bhatt… - Blood cancer …, 2016 - nature.com
Abstract Toll-like receptor 2 (TLR2) is a member of the TLR family of receptors that play a
central role in innate immunity. In addition to regulating effector immune cells, where it …
central role in innate immunity. In addition to regulating effector immune cells, where it …
Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin
Bacterial products (such as endotoxins and flagellin) trigger innate immune responses
through TLRs. Flagellin‐induced signalling involves TLR5 and MyD88 and, according to …
through TLRs. Flagellin‐induced signalling involves TLR5 and MyD88 and, according to …
[HTML][HTML] A critical role of toll-like receptor 4 (TLR4) and its' in vivo ligands in basal radio-resistance
C Liu, C Zhang, REJ Mitchel, J Cui, J Lin, Y Yang… - Cell death & …, 2013 - nature.com
Abstract Toll-like receptor-4 (TLR4) plays a critical role in innate and acquired immunity, but
its role in radio-resistance is unknown. We used TLR4 knockout (KO,−/−) mice and gut …
its role in radio-resistance is unknown. We used TLR4 knockout (KO,−/−) mice and gut …
Toll-like receptor 2-deficiency on bone marrow-derived cells augments vascular healing of murine arterial lesions
W Liu, JC Eczko, M Otto, R Bajorat, B Vollmar… - Life sciences, 2020 - Elsevier
Aims Neointimal hyperplasia contributes to arterial restenosis after percutaneous
transluminal coronary angioplasty or vascular surgery. Neointimal thickening after arterial …
transluminal coronary angioplasty or vascular surgery. Neointimal thickening after arterial …