Preclinical models for drug discovery for metastatic disease

L Wakefield, S Agarwal, K Tanner - Cell, 2023 - cell.com
Despite many advances, metastatic disease remains essentially uncurable. Thus, there is an
urgent need to better understand mechanisms that promote metastasis, drive tumor …

[HTML][HTML] Cell lines of circulating tumor cells: what is known and what needs to be resolved

Y Shimada, T Sudo, S Akamatsu, T Sunada… - Journal of Personalized …, 2022 - mdpi.com
The importance of circulating tumor cells (CTC) is well recognized. However, the biological
characteristics of CTC in the bloodstream have not yet been examined in detail, due to the …

[HTML][HTML] Conditionally reprogrammed cells and robotic high-throughput screening for precision cancer therapy

F Alkhilaiwi - Frontiers in Oncology, 2021 - frontiersin.org
Cancer is a devastating disease that takes the lives of millions of people globally every year.
Precision cancer therapy is based on a patient's tumor histopathology, expression analyses …

State of the Art in the Propagation of Circulating Tumor Cells

J Xiao, PR Pohlmann, R Schlegel… - Circulating Tumor Cells …, 2023 - Springer
Circulating tumor cells (CTCs) are a group of cells that travel through the circulatory system
of a cancer patient, sowing distant sites and forming the seeds for metastatic nodules. Given …

[BOOK][B] Investigating the Mechanisms of Cancer Metastasis Through Novel in Vitro and in Vivo Models

J Xiao - 2022 - search.proquest.com
Cancer is the second highest cause of death globally. In an estimated 90% of all cases, the
spread of cancer cells from the initial tumor to a distant site—aka metastasis—is the primary …

Clinical significance of circulating tumor cells testing in auxiliary diagnosis ofgastrointestinal cancer

W Zhaoxia, Z Lei - Indian Journal of Experimental Biology (IJEB), 2022 - or.niscpr.res.in
Routine diagnostic tools and serum biomarkers of gastrointestinal (GI) cancer has limits in
detecting early and micrometastasis, and circulating tumor cells (CTCs) had emerged as a …

[HTML][HTML] Detection of Circulating Tumor Cells Using Three-dimensional and Conditionally Reprogrammed Culture Methods

C Park, YJ Jeong, SH Park, DD Kim… - Laboratory Medicine … - synapse.koreamed.org
Background Circulating tumor cells (CTCs) are rare in the circulation of patients with tumors
and are very difficult to detect. In this study, we cultured CTCs in a three-dimensionally …