[HTML][HTML] The onset of in-vivo dehydration in gas-based intraperitoneal hyperthermia and its cytotoxic effects on colon cancer cells

A Diakun, T Khosrawipour… - Frontiers in …, 2022 - frontiersin.org
Background: Peritoneal metastasis (PM) is an ongoing challenge in surgical oncology.
Current therapeutic options, including intravenous and intraperitoneal (ip) chemotherapies …

[HTML][HTML] In-vivo thermodynamic exploration of gas-based intraperitoneal hyperthermia

A Diakun, T Khosrawipour… - Frontiers in …, 2022 - frontiersin.org
Background: While hyperthermic intraperitoneal (ip) applications are highly efficient in
treating peritoneal metastases (PM), they are currently limited to temperatures of 41–43° …

[HTML][HTML] Safety, feasibility, and application of intraperitoneal gas-based hyperthermia beyond 43° C in the treatment of peritoneal metastasis: An in-vivo pilot study

A Diakun, T Khosrawipour… - Frontiers in …, 2022 - frontiersin.org
Background: 43° Celsius (C) is currently the highest temperature used in the treatment of
peritoneal metastasis (PM). Despite sufficient data on water-based hyperthermic solutions in …

[HTML][HTML] Triple-Therapy of Peritoneal Metastasis—Partial-Dehydration under Hyperthermic Condition Combined with Chemotherapy: The First Preliminary In-Vitro …

C Khosrawipour, A Diakun, S Li, H Lau, J Kulas… - Pharmaceuticals, 2023 - mdpi.com
A newly introduced combination of intraperitoneal dehydration and hyperthermia has
recently been shown to be feasible and cytotoxic for colon cancer cells in vivo. For the first …

[HTML][HTML] Creating nanocrystallized chemotherapy: The differences in pressurized aerosol chemotherapy (PAC) via intracavitary (IAG) and extracavitary aerosol …

T Khosrawipour, J Schubert, J Kulas, P Migdal… - Journal of …, 2020 - ncbi.nlm.nih.gov
Background: Nanocrystallization is a promising field for the development of new drugs. This
study aims to present the use of nanocrystallization via intraperitoneal nanoaerosol therapy …

[HTML][HTML] Intrathoracic aerosol chemotherapy via spray‑catheter

V Khosrawipour, A Mikolajczyk… - Molecular and …, 2020 - spandidos-publications.com
Pressurized intrathoracic aerosol chemotherapy (PITAC) has been introduced to the clinical
setting as a novel treatment option for pleural metastasis (PM). For decades the therapeutic …

[HTML][HTML] Evaluating the concept of gas‑based intraperitoneal hyperthermia beyond 43˚ C in the treatment of peritoneal metastasis: A pilot study

S Thelen, A Mikolajczyk-Martinez… - Experimental and …, 2022 - spandidos-publications.com
While hyperthermic intraperitoneal applications have demonstrated high efficacy in treating
peritoneal metastases (PM), these applications are limited to temperatures of 41‑43 C to …

[HTML][HTML] Release of doxorubicin from its liposomal coating via high intensity ultrasound

A Mikolajczyk, V Khosrawipour… - Molecular and …, 2019 - spandidos-publications.com
The present ex vivo study was performed to analyze the impact of high intensity ultrasound
(HIUS) on penetration depth and particle stability of liposomal doxorubicin (LD) on the …

[HTML][HTML] Increased tissue penetration of doxorubicin in pressurized intraperitoneal aerosol chemotherapy (PIPAC) after high-intensity ultrasound (HIUS)

V Khosrawipour, S Reinhard, A Martino… - International Journal of …, 2019 - hindawi.com
Background. High‐intensity ultrasound (HIUS) has been studied for the past two decades as
a new therapeutic option for solid tumor direct treatment and a method for better …

[HTML][HTML] Exploring Insulin Production Following Alveolar Islet Transplantation (AIT)

H Lau, T Khosrawipour, S Li, M Alexander… - International journal of …, 2021 - mdpi.com
Recent studies have demonstrated the feasibility of islet implantation into the alveoli.
However, until today, there are no data on islet behavior and morphology at their transplant …