Endogenous opiates and behavior: 2014

RJ Bodnar - Peptides, 2016 - Elsevier
This paper is the thirty-seventh consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2014 …

Discovery of GSK2795039, a novel small molecule NADPH oxidase 2 inhibitor

K Hirano, WS Chen, ALW Chueng… - Antioxidants & redox …, 2015 - liebertpub.com
Abstract Aims: The NADPH oxidase (NOX) family of enzymes catalyzes the formation of
reactive oxygen species (ROS). NOX enzymes not only have a key role in a variety of …

[HTML][HTML] Independent evolution of pain insensitivity in African mole-rats: origins and mechanisms

ESJ Smith, TJ Park, GR Lewin - Journal of Comparative Physiology A, 2020 - Springer
The naked mole-rat (Heterocephalus glaber) is famous for its longevity and unusual
physiology. This eusocial species that lives in highly ordered and hierarchical colonies with …

Analgesic and anti-inflammatory effects and molecular mechanisms of Kadsura heteroclita stems, an anti-arthritic Chinese Tujia ethnomedicinal herb

H Yu, Y Lin, R Zeng, X Li, T Zhang, S Tasneem… - Journal of …, 2019 - Elsevier
Ethnopharmacological relevance Rheumatoid arthritis (RA) is a chronic autoimmune
disease characterized by failure of spontaneous resolution of inflammation. The stem of …

The somatosensory world of the African naked mole-rat

GR Lewin, ESJ Smith, J Reznick, K Debus… - … Extraordinary Biology of …, 2021 - Springer
The naked mole-rat (Heterocephalus glaber) is famous for its longevity and unusual
physiology. This eusocial species that lives in highly ordered and hierarchical colonies with …

[HTML][HTML] Antinociceptive Activity of Zanthoxylum piperitum DC. Essential Oil

GR Donald, PD Fernandes, F Boylan - … -Based Complementary and …, 2016 - hindawi.com
Zanthoxylum piperitum DC.(ZP) is a traditional medicinal plant used mainly in countries from
Asia such as Japan. This study aimed to investigate the antinociceptive effect of ZP essential …

[HTML][HTML] The naked mole-rat has a functional purinergic pain pathway despite having a non-functional peptidergic pain pathway

BM Browe, AR Olsen, C Ramirez, RH Rickman… - Neurobiology of Pain, 2020 - Elsevier
Naked mole-rats (Heterocephalus glaber) have adaptations within their pain pathway that
are beneficial to survival in large colonies within poorly ventilated burrow systems, with …

Central possible antinociceptive mechanism of naringin

ME Okur, ÇK Karayildirim - İstanbul Journal of Pharmacy, 2021 - dergipark.org.tr
Background and Aims: The object of this study was the investigation of the central
antinociceptive effects of naringin as well as the association of stimulation of opioidergic …

Combination of stressors in the critical periods of development increases resistance to inflammatory pain stress in adult rats

IP Butkevich, VA Mikhailenko, EA Vershinina - … and Behavioral Physiology, 2020 - Springer
We report here studies of the long-term effects of combined stress in the prenatal and
prepubertal periods of development on measures of tonic inflammatory pain in the formalin …

The effective synthesis of N-(arylalkyl)-1-R-4-hydroxy-2, 2-dioxo-1H-2λ6, 1-benzothiazine-3-carboxamides as promising analgesics of a new chemical class

IV Ukrainets, LA Petrushova, SP Dzyubenko… - Scientia …, 2015 - mdpi.com
A new, effective preparative method has been proposed and the synthesis of a series of N-
(arylalkyl)-1-R-4-hydroxy-2, 2-dioxo-1 H-2λ 6, 1-benzothiazine-3-car-boxamides has been …