The design of C 2-symmetric biologically active molecules is a subject of interest to the
scientific community. It provides the possibility of discovering medicine with higher biological …

This review discusses the relationship of the efflux pump (EP) system of Gram-negative
bacteria to other antibiotic resistance mechanisms of the bacterium such as quorum sensing …

Numerous studies show efflux as a universal bacterial mechanism contributing to antibiotic
resistance and also that the activity of the antibiotics subject to efflux can be enhanced by …

Given the ability of M. tuberculosis to survive as an intracellular pathogen and its propensity
to develop resistance to the existing antituberculosis drugs, its treatment requires new …

Drug resistant tuberculosis continues to increase and new approaches for its treatment are
necessary. The identification of M. tuberculosis clinical isolates presenting efflux as part of …

Tuberculosis remains one of the deadliest infectious diseases in the world, and the
increased number of multidrug-resistant and extremely drug-resistant strains is a significant …

Efflux pumps are membrane proteins capable of actively transporting a broad range of
substrates from the cytoplasm to the exterior of the cell. Increased efflux activity in response …

Purpose. The mechanisms underlying colistin heteroresistance in Acinetobacter baumannii
are not fully understood. Here, we investigated the role of efflux in colistin-heteroresistant …

The basis of drug resistance in Mycobacterium abscessus is still poorly understood.
Nevertheless, as seen in other microorganisms, the efflux of antimicrobials may also play a …

Hydantoin derivatives are commonly used anticonvulsants. In general, they are effective for
partial-onset seizures and tonic-clonic seizures, but not for absence seizures. Phenytoin is …