Metabolic regulation of macrophage polarization in cancer

K Mehla, PK Singh - Trends in cancer, 2019 - cell.com
Macrophages act as scavengers, modulating the immune response against pathogens and
maintaining tissue homeostasis. Metabolism governs macrophage differentiation …

Metabolite profiling identifies pathways associated with metabolic risk in humans

S Cheng, EP Rhee, MG Larson, GD Lewis… - Circulation, 2012 - Am Heart Assoc
Background—Although metabolic risk factors are known to cluster in individuals who are
prone to developing diabetes mellitus and cardiovascular disease, the underlying biological …

Microglia immunometabolism: From metabolic disorders to single cell metabolism

RC Paolicelli, S Angiari - Seminars in cell & developmental biology, 2019 - Elsevier
Since the observation that obesity-associated low-grade chronic inflammation is a crucial
driver for the onset of systemic metabolic disorders such as type 2 diabetes, a number of …

Use of integrated metabolomics, transcriptomics, and signal protein profile to characterize the effector function and associated metabotype of polarized macrophage …

CB Anders, TMW Lawton, HL Smith… - Journal of leukocyte …, 2022 - academic.oup.com
MΦs display remarkable plasticity and the ability to activate diverse responses to a host of
intracellular and external stimuli. Despite extensive characterization of M1 MΦs and a broad …

Non-targeted metabolite profiling in activated macrophage secretion

M Sugimoto, H Sakagami, Y Yokote, H Onuma… - Metabolomics, 2012 - Springer
Periodontal diseases are inflammatory infectious diseases that affect the periodontal tissue.
Macrophages play a central role in inflammatory conditions, leading to the destruction of …

Effect of timing of collection of salivary metabolomic biomarkers on oral cancer detection

S Ishikawa, M Sugimoto, K Kitabatake, M Tu, A Sugano… - Amino acids, 2017 - Springer
The aim of this study is to evaluate the effect of duration after meals for saliva collections for
oral cancer detection using metabolomics. Saliva samples were collected from oral cancer …

Arginine and glutamine supplementation to culture media improves the performance of various channel catfish immune cells

C Pohlenz, A Buentello, W Mwangi… - Fish & shellfish …, 2012 - Elsevier
Specific components of both the innate and adaptive immune systems of channel catfish
were evaluated after supplementation of culture media with arginine (ARG) and/or glutamine …

Mechanism of taurine reducing inflammation and organ injury in sepsis mice

Y Ma, Y Zhang, R Li, S Deng, Q Qin, C Ran, Y Hao… - Cellular …, 2022 - Elsevier
The fundamental basis for the pathogenesis of sepsis is an inflammatory imbalance, which
is considered to be the main target for treatment. Taurine is an intracellular free amino acid …

Metabolism in tumor-associated macrophages

J Li, GM DeNicola, B Ruffell - International review of cell and molecular …, 2022 - Elsevier
Macrophages functionally adapt to a diverse set of signals, a process that is critical for their
role in maintaining or restoring tissue homeostasis. This process extends to cancer, where …

[HTML][HTML] A targeted serum metabolomics GC-MS approach identifies predictive blood biomarkers for retained placenta in Holstein dairy cows

G Zhang, D Tobolski, G Zwierzchowski, R Mandal… - Metabolites, 2021 - mdpi.com
The retained placenta is a common pathology of dairy cows. It is associated with a
significant drop in the dry matter intake, milk yield, and increased susceptibility of dairy cows …