Clinical translation of advanced colonic drug delivery technologies

A Awad, CM Madla, LE McCoubrey, F Ferraro… - Advanced drug delivery …, 2022 - Elsevier
Targeted drug delivery to the colon offers a myriad of benefits, including treatment of local
diseases, direct access to unique therapeutic targets and the potential for increasing …

Determinants of metastatic competency in colorectal cancer

DVF Tauriello, A Calon, E Lonardo… - Molecular …, 2017 - Wiley Online Library
Colorectal cancer (CRC) is one of the most common cancer types and represents a major
therapeutic challenge. Although initial events in colorectal carcinogenesis are relatively well …

Current status of immunotherapy in metastatic colorectal cancer

P Wrobel, S Ahmed - International journal of colorectal disease, 2019 - Springer
Background Immunotherapy focuses on selectively enhancing the host's immune response
against malignant disease. It has been investigated as an important treatment modality …

[HTML][HTML] Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2-and Src‑mediated phosphorylation of …

J Kundu, BY Choi, CH Jeong… - Oncology …, 2014 - spandidos-publications.com
Thymoquinone (TQ), a compound isolated from black seed oil (Nigella sativa), has been
reported to possess anti-inflammatory and anticancer activities. However, the molecular …

[HTML][HTML] N6-Methyladenosine Modification of PTTG3P Contributes to Colorectal Cancer Proliferation via YAP1

Y Zheng, Y Wang, Y Liu, L Xie, J Ge, G Yu… - Frontiers in …, 2021 - frontiersin.org
Background Long noncoding RNAs (lncRNAs) have emerged to have irreplaceable roles in
the epigenetic regulation of cancer progression, but their biological functions in colorectal …

Treating colon cancers with a non-conventional yet strategic approach: An overview of various nanoparticulate systems

NA Bhaskaran, L Kumar - Journal of Controlled Release, 2021 - Elsevier
Regardless of progress in therapy management which are developed for colon cancer (CC),
it remains the third most common cause of mortality due to cancers around the world …

[HTML][HTML] Clinicopathological and prognostic significance of PD-L1 expression in colorectal cancer: a systematic review and meta-analysis

Z Shen, L Gu, D Mao, M Chen, R Jin - World journal of surgical oncology, 2019 - Springer
Objective To analyze the prognostic value of programmed death factor ligand 1 (PD-L1) in
colorectal cancer. Methods Electronic databases, such as PubMed, Web of Science …

[HTML][HTML] Long-term survival of patients with stage III colon cancer treated with VRP-CEA (6D), an alphavirus vector that increases the CD8+ effector memory T cell to …

EJ Crosby, AC Hobeika, D Niedzwiecki… - … for Immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background There remains a significant need to eliminate the risk of recurrence of resected
cancers. Cancer vaccines are well tolerated and activate tumor-specific immune effectors …

Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells

DH Kim, KW Park, IG Chae, J Kundu… - Molecular …, 2016 - Wiley Online Library
Carnosic acid (CA), the main antioxidant compound of Rosmarinus officinalis L., has been
reported to possess anticancer activity. However, the molecular mechanisms underlying the …

[HTML][HTML] Carnosol induces apoptosis through generation of ROS and inactivation of STAT3 signaling in human colon cancer HCT116 cells

KW Park, J Kundu, IG Chae… - International …, 2014 - spandidos-publications.com
Carnosol, an active constituent of rosemary, has been reported to possess anti-inflammatory
and anticancer activities. However, the molecular mechanisms underlying the anticancer …