Bacterial biofilm formation on indwelling urethral catheters

H Pelling, J Nzakizwanayo, S Milo… - Letters in applied …, 2019 - academic.oup.com
Urethral catheters are the most commonly deployed medical devices and used to manage a
wide range of conditions in both hospital and community care settings. The use of long‐term …

Addressing the tuberculosis–depression syndemic to end the tuberculosis epidemic

AC Sweetland, A Kritski, MA Oquendo… - … of Tuberculosis and …, 2017 - ingentaconnect.com
Tuberculosis (TB) and depression act synergistically via social, behavioral, and biological
mechanisms to magnify the burden of disease. Clinical depression is a common, under …

[HTML][HTML] Efflux pumps of Gram-negative bacteria: what they do, how they do it, with what and how to deal with them

L Amaral, A Martins, G Spengler… - Frontiers in pharmacology, 2014 - frontiersin.org
This review discusses the relationship of the efflux pump (EP) system of Gram-negative
bacteria to other antibiotic resistance mechanisms of the bacterium such as quorum sensing …

Targeting Type IV pili as an antivirulence strategy against invasive meningococcal disease

K Denis, M Le Bris, L Le Guennec, JP Barnier… - Nature …, 2019 - nature.com
Bacterial virulence factors are attractive targets for the development of therapeutics. Type IV
pili, which are associated with a remarkable array of properties including motility, the …

[HTML][HTML] Thioridazine: A non-antibiotic drug highly effective, in combination with first line anti-tuberculosis drugs, against any form of antibiotic resistance of …

L Amaral, M Viveiros - Antibiotics, 2017 - mdpi.com
This review presents the evidence that supports the use of thioridazine (TZ) for the therapy of
a pulmonary tuberculosis infection regardless of its antibiotic resistance status. The …

Efflux inhibition by selective serotonin reuptake inhibitors in Escherichia coli

JA Bohnert, M Szymaniak-Vits… - Journal of …, 2011 - academic.oup.com
Objectives To evaluate the antimicrobial and synergistic (hypothetically due to the inhibition
of efflux pumps) effects of selective serotonin reuptake inhibitors (SSRIs) in Escherichia coli …

New multidrug efflux inhibitors for Gram-negative bacteria

RL Marshall, GS Lloyd, AJ Lawler, SJ Element, J Kaur… - Mbio, 2020 - Am Soc Microbiol
Active efflux of antibiotics preventing their accumulation to toxic intracellular concentrations
contributes to clinically relevant multidrug resistance. Inhibition of active efflux potentiates …

In vitro and in silico studies of chalcones derived from natural acetophenone inhibitors of NorA and MepA multidrug efflux pumps in Staphylococcus aureus

TS Freitas, JC Xavier, RLS Pereira, JE Rocha… - Microbial …, 2021 - Elsevier
Bacterial resistance induced by efflux pumps is a frequent concern in clinical treatments
involving multi-resistant bacteria. Staphylococcus aureus is a microorganism responsible for …

[HTML][HTML] An integrated in silico based subtractive genomics and reverse vaccinology approach for the identification of novel vaccine candidate and chimeric vaccine …

K Khan, K Jalal, R Uddin - Genomics, 2022 - Elsevier
Salmonella typhi is notorious for causing enteric fever which is also known as typhoid fever.
It emerged as an extreme drug resistant strain that requires urgent attention to prevent its …

Why thioridazine in combination with antibiotics cures extensively drug-resistant Mycobacterium tuberculosis infections

L Amaral, M Viveiros - International journal of antimicrobial agents, 2012 - Elsevier
Thioridazine (TDZ) in combination with antibiotics to which extensively drug-resistant
Mycobacterium tuberculosis (XDR-TB) is initially resistant yields a cure. This is due to the …