The pathogenesis of acute myocardial infarction is known to be mediated by systemic,
intraplaque and myocardial inflammatory processes. Among different immune cell subsets …

Statins, a common drug class for treatment of dyslipidemia, may be neuroprotective for
spontaneous intracerebral hemorrhage (ICH) by targeting secondary brain injury pathways …

Rationale: Hemizygous deficiency of the transcription factor Krüppel-like factor 2 (KLF2) has
been shown previously to augment atherosclerosis in hypercholesterolemic mice. However …

Introduction Treatment of acute lung injury (ALI) remains an unsolved problem in intensive
care medicine. As simvastatin exerts protective effects in inflammatory diseases we explored …

Inhibitors of HMG-CoA reductase (statins) are the major group of lipid-lowering drugs. Along
with hypocholesterolemic activity, statins exhibit anti-inflammatory and immunomodulatory …

Background—Although newer immunosuppressive agents, such as mTOR (mammalian
target of rapamycin) inhibitors, have lowered the occurrence of malignancies after …

New Findings What is the central question of this study? Are circulating monocyte markers
correlated with their derived macrophage polarization patterns and coronary artery disease …

Dehydrogingerdione is a novel cholesteryl ester transfer protein (CETP) inhibitor of natural
origin. Some synthetic CETP inhibitors have recently been reported to suppress proprotein …

Emphysema results in a proteinase–antiproteinase imbalance, inflammation and oxidative
stress. Our objective was to investigate whether atorvastatin could repair mouse lungs after …

Purpose The underlying mechanism of pleiotropic effects of statins on atherosclerosis is still
unclear. Kv1. 3 and KCa3. 1 are two potassium channels that might be involved in monocyte …