2-Methoxyestradiol reverses the pro-carcinogenic effect of L-lactate in osteosarcoma 143B cells

M Gorska-Ponikowska… - Cancer Genomics & …, 2017 - cgp.iiarjournals.org
Background/Aim: According to the reverse Warburg effect, tumor cells may metabolize
lactate as an energy source and shuttle L-lactate to neighboring cancer cells, adjacent …

2-Methoxyestradiol affects mitochondrial biogenesis pathway and succinate dehydrogenase complex flavoprotein subunit A in osteosarcoma cancer cells

M Gorska-Ponikowska… - Cancer Genomics & …, 2018 - cgp.iiarjournals.org
Background/Aim: Dysregulation of mitochondrial pathways is implicated in several diseases,
including cancer. Notably, mitochondrial respiration and mitochondrial biogenesis are …

CYP1 和 COMT 介导的雌二醇代谢与乳腺癌的关系及相关抗癌药的研发思路

杨文亮, 柳晓泉 - 药学进展, 2010 - cqvip.com
雌二醇代谢在乳腺, 子宫和卵巢等雌激素相关器官以及肿瘤组织内主要由细胞色素P450 酶1
(CYP1) 和儿茶酚甲基转移酶(COMT) 所介导. 这两种酶与乳腺癌的发生发展密切相关 …