Deoxynivalenol (DON) is one of the most common mycotoxins in cereals and their by-
products. Its adverse effects on animal and human health have been extensively studied in …

Apoptosis not only plays a key role in physiological demise of defunct hepatocytes, but is
also associated with a plethora of acute and chronic liver diseases as well as with …

The liver is the central metabolic organ in the human body, and also plays an essential role
in innate and adaptive immunity. While mouse models offer significant insights into immune …

Drug-induced organ injury is a multifaceted process, involving numerous cell types and
mediators, and remains a significant safety issue in pharmaceutical development and …

Breast cancer is the leading cause of death in women worldwide. The search for novel
compounds with antitumor activity, with less adverse effects and higher efficacy, and the …

Precision cut liver slices (PCLiS) represent a promising tool in reflecting hepatotoxic
responses. However, the culture of PCLiS varies considerably between laboratories, which …

Cultures of precision‐cut tissue slices allow the investigation of substance effects on human
tissues under in vivo‐like conditions over a limited time span. We have adapted the model …

Nonsteroidal anti-inflammatory drugs are known to reduce the risk and mortality from
colorectal carcinoma by inhibiting cyclo-oxygenases (COX). COX-2 expression was …

Precision cut tissue slices (PCTS) represent a suitable and convenient tool for
pharmacological, toxicological and morphological studies. Cryopreservation would enable …

Background: Therapeutic options in patients with metastatic colorectal cancer are still
limited. As apoptosis contributes to the overall sensitivity to radiotherapy or chemotherapy, a …