Plasma levels of soluble PD-L1 correlate with tumor regression in patients with lung and gastric cancer treated with immune checkpoint inhibitors

…, Y Kubota, H Matsui, T Ishiguro, Y Hirasawa… - Anticancer …, 2019 - ar.iiarjournals.org
Background/Aim: Cancer immune therapy by immune checkpoint inhibitors (ICIs) is a promising
therapeutic strategy for various cancer types. Among ICIs, anti-programmed cell death …

[HTML][HTML] Increased plasma soluble PD-1 concentration correlates with disease progression in patients with cancer treated with anti-PD-1 antibodies

…, Y Kubota, A Horiike, T Ishiguro, Y Hirasawa… - Biomedicines, 2021 - mdpi.com
Immune checkpoint inhibitors (ICIs) confer remarkable therapeutic benefits to patients with
various cancers. However, many patients are non-responders or develop resistance following …

[HTML][HTML] Monocyte subsets associated with the efficacy of anti‑PD‑1 antibody monotherapy

…, K Hamada, H Ariizumi, Y Hirasawa… - Oncology …, 2023 - spandidos-publications.com
Immune checkpoint inhibitors (ICIs) are among the most notable advances in cancer
immunotherapy; however, reliable biomarkers for the efficacy of ICIs are yet to be reported. …

A high number of PD-L1+ CD14+ monocytes in peripheral blood is correlated with shorter survival in patients receiving immune checkpoint inhibitors

…, A Horiike, H Matsui, T Ishiguro, Y Hirasawa… - Cancer Immunology …, 2021 - Springer
Purpose Targeting of anti-programmed cell death protein-1 (PD-1) and anti-programmed
death-ligand 1 (PD-L1) is a standard therapeutic strategy for various cancers. The aim of the …

Antibiotic usage reduced overall survival by over 70% in non-small cell lung cancer patients on anti-PD-1 immunotherapy

K Hamada, K Yoshimura, Y Hirasawa… - Anticancer …, 2021 - ar.iiarjournals.org
Background/Aim: There is an increasing use of immunotherapy for non-small cell lung cancer
(NSCLC) patients. The present study analysed the effect of antibiotic use on the outcome …

[HTML][HTML] High expression of olfactomedin-4 is correlated with chemoresistance and poor prognosis in pancreatic cancer

…, Y Kubota, K Hamada, H Ishida, Y Hirasawa… - PLoS …, 2020 - journals.plos.org
Pancreatic cancer has an extremely poor prognosis, and identification of novel predictors of
therapeutic efficacy and prognosis is urgently needed. Chemoresistance-related molecules …

The prognostic impact of eosinophils and the eosinophil-to-lymphocyte ratio on survival outcomes in stage II resectable pancreatic cancer

…, Y Kubota, A Horiike, T Ishiguro, Y Hirasawa… - Pancreas, 2021 - journals.lww.com
Objectives The relationship between eosinophils and cancer prognosis is unknown. Therefore,
we analyzed the relationship between circulating eosinophils and the survival of stage …

[HTML][HTML] A case report on severe nivolumab-induced adverse events similar to primary sclerosing cholangitis refractory to immunosuppressive therapy

Y Hirasawa, K Yoshimura, H Matsui, Y Kubota… - Medicine, 2021 - journals.lww.com
A case report on severe nivolumab-induced adverse events sim... : Medicine A case report
on severe nivolumab-induced adverse events similar to primary sclerosing cholangitis …

[HTML][HTML] A case of bronchial asthma as an immune-related adverse event of pembrolizumab treatment for bladder cancer: a case report

K Hamada, K Yoshimura, K Oshinomi, Y Hirasawa… - Medicine, 2022 - journals.lww.com
A case of bronchial asthma as an immune-related adverse even... : Medicine A case of
bronchial asthma as an immune-related adverse event of pembrolizumab treatment for bladder …

[HTML][HTML] High expression levels of polymeric immunoglobulin receptor are correlated with chemoresistance and poor prognosis in pancreatic cancer

…, A Horiike, T Ishiguro, Y Hirasawa… - Oncology …, 2020 - spandidos-publications.com
Pancreatic cancer has extremely poor prognosis, warranting the discovery of novel therapeutic
and prognostic markers. The expression of polymeric immunoglobulin receptor (pIgR), a …