Lack of common NOD2 variants in Japanese patients with Crohn's disease
N Inoue, K Tamura, Y Kinouchi, Y Fukuda, S Takahashi… - Gastroenterology, 2002 - Elsevier
Background & Aims: Previous studies have linked Crohn's disease (CD) to the pericentromeric
region of chromosome 16 (IBD1). Three independent studies of Western populations …
region of chromosome 16 (IBD1). Three independent studies of Western populations …
Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries
…, M Nagasaki, J Umeno, K Tokunaga, Y Kinouchi… - Nature …, 2023 - nature.com
Inflammatory bowel diseases (IBDs) are chronic disorders of the gastrointestinal tract with
the following two subtypes: Crohn’s disease (CD) and ulcerative colitis (UC). To date, most …
the following two subtypes: Crohn’s disease (CD) and ulcerative colitis (UC). To date, most …
Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF-κB transcription factors
…, AP De Silva, DP McGovern, Y Kinouchi… - Human molecular …, 2002 - academic.oup.com
Tumour necrosis factor-α (TNF) expression is increased in inflammatory bowel disease (IBD),
and TNF maps to the IBD3 susceptibility locus. Transmission disequilibrium and case–…
and TNF maps to the IBD3 susceptibility locus. Transmission disequilibrium and case–…
A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population
…, T Matsumoto, T Matsui, Y Kakuta, Y Kinouchi… - Nature …, 2009 - nature.com
Ulcerative colitis is one of the principal forms of inflammatory bowel disease with complex
manifestations. Although previous studies have indicated that there is a genetic contribution to …
manifestations. Although previous studies have indicated that there is a genetic contribution to …
Differential expression of mucosal addressin cell adhesion molecule‐1 (MAdCAM‐1) in ulcerative colitis and Crohn's disease
…, M Murata, C Ejima, M Oki, Y Kinouchi… - Pathology …, 2002 - Wiley Online Library
Mucosal addressin cell adhesion molecule‐1 (MAdCAM‐1) is selectively expressed in the
endothelial cells of intestinal mucosa and gut‐associated lymphoid tissue (GALT). …
endothelial cells of intestinal mucosa and gut‐associated lymphoid tissue (GALT). …
[HTML][HTML] NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory …
…, H Hanai, A Andoh, M Nagasaki, Y Kinouchi… - Journal of …, 2018 - Springer
Background Despite NUDT15 variants showing significant association with thiopurine-induced
adverse events (AEs) in Asians, it remains unclear which variants of NUDT15 or whether …
adverse events (AEs) in Asians, it remains unclear which variants of NUDT15 or whether …
Crohn's disease is associated with novel polymorphisms in the 5'-flanking region of the tumor necrosis factor gene
K Negoro, Y Kinouchi, N Hiwatashi, S Takahashi… - Gastroenterology, 1999 - Elsevier
Background & Aims: Tumor necrosis factor (TNF) is considered to play an important role in
the pathogenesis of Crohn's disease (CD). Recently, 3 polymorphisms in the 5'-flanking …
the pathogenesis of Crohn's disease (CD). Recently, 3 polymorphisms in the 5'-flanking …
[HTML][HTML] MicroRNA-320 family is downregulated in colorectal adenoma and affects tumor proliferation by targeting CDK6
…, A Masamune, S Takahashi, Y Kinouchi… - World journal of …, 2016 - ncbi.nlm.nih.gov
AIM: To investigate the microRNA (miRNA) expression during histological progression from
colorectal normal mucosa through adenoma to carcinoma within a lesion. METHODS: Using …
colorectal normal mucosa through adenoma to carcinoma within a lesion. METHODS: Using …
FCGR3A-158 polymorphism influences the biological response to infliximab in Crohn's disease through affecting the ADCC activity
R Moroi, K Endo, Y Kinouchi, H Shiga, Y Kakuta… - Immunogenetics, 2013 - Springer
An association between FCGR3A-158 V/F polymorphism and biological responses to
infliximab has been reported in Crohn’s disease (CD) in Western countries. However, little is …
infliximab has been reported in Crohn’s disease (CD) in Western countries. However, little is …
Potential Antitumor-Promoting Diterpenoids from the Stem Bark of Picea glehni
Y Kinouchi, H Ohtsu, H Tokuda, H Nishino… - Journal of natural …, 2000 - ACS Publications
A novel rearranged labdane-type diterpenoid, 19(4→3)abeo-8α,13(S)-epoxylabda-4(18),14-diene
(1), and two new abietane-type diterpenoids, 19-nor-abieta-4(18),8,11,13-tetraen-7-…
(1), and two new abietane-type diterpenoids, 19-nor-abieta-4(18),8,11,13-tetraen-7-…