[HTML][HTML] Nitric oxide increases the invasion of pancreatic cancer cells via activation of the PI3K–AKT and RhoA pathways after carbon ion irradiation

M Fujita, K Imadome, S Endo, Y Shoji, S Yamada… - FEBS letters, 2014 - Elsevier
Previous studies have shown that serine proteases and Rho-associated kinase contribute
to carbon ion radiation-enhanced invasion of the human pancreatic cancer cell line PANC-1. …

Efficacy and safety of difelikefalin in Japanese patients with moderate to severe pruritus receiving hemodialysis: a randomized clinical trial

…, Y Ushiogi, Y Akamatsu, Y Otsubo, Y Shoji… - JAMA Network …, 2022 - jamanetwork.com
Importance Patients with pruritus receiving hemodialysis frequently experience oppressive
physical and psychiatric symptoms that directly affect their quality of life and increase mortality…

Combination effects of distinct cores in 11q13 amplification region on cervical lymph node metastasis of oral squamous cell carcinoma

…, Y Michikawa, K Ishikawa, Y Shoji… - International …, 2011 - spandidos-publications.com
Lymph node metastasis (LNM) in oral squamous cell carcinoma (OSCC) is known to associate
with a significant decrease of 5-year survival. Genetic factors related to the difference of …

[HTML][HTML] Importance of locations of iron ions to elicit cytotoxicity induced by a fenton-type reaction

K Igarashi, Y Shoji, E Sekine-Suzuki, M Ueno… - Cancers, 2022 - mdpi.com
Simple Summary The Fenton reaction generates the hydroxyl radical ( • OH), which is the
most reactive and toxic reactive oxygen species and widely recognized as a key player in …

[HTML][HTML] Carbon-ion irradiation suppresses migration and invasiveness of human pancreatic carcinoma cells MIAPaCa-2 via Rac1 and RhoA degradation

M Fujita, K Imadome, Y Shoji, T Isozaki, S Endo… - International Journal of …, 2015 - Elsevier
Purpose To investigate the mechanisms underlying the inhibition of cancer cell migration
and invasion by carbon (C)-ion irradiation. Methods and Materials Human pancreatic cancer …

Genetic variants in CD44 and MAT1A confer susceptibility to acute skin reaction in breast cancer patients undergoing radiation therapy

…, DJ Fernandes, BM Vadhiraja, T Suga, Y Shoji… - International Journal of …, 2017 - Elsevier
Purpose Heterogeneity in radiation therapy (RT)-induced normal tissue toxicity is observed
in 10% of cancer patients, limiting the therapeutic outcomes. In addition to treatment-related …

[HTML][HTML] A large kinetic isotope effect in the reaction of ascorbic acid with 2-phenyl-4, 4, 5, 5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO˙) in aqueous buffer solutions

I Nakanishi, Y Shoji, K Ohkubo, T Ozawa… - Chemical …, 2020 - pubs.rsc.org
A large kinetic isotope effect (KIE, kH/kD) of 12.8 was observed for the hydrogen-transfer
reaction from ascorbic acid to 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO) in …

Heavy-ion beam-induced reactive oxygen species and redox reactions

K Matsumoto, M Ueno, Y Shoji… - Free Radical …, 2021 - Taylor & Francis
Quantification and local density estimation of radiation-induced reactive oxygen species (ROS)
were described focusing on our recent and related studies. Charged particle radiation, ie …

Anti-cancer Effect of a Planar Catechin Analog through the Decrease in Mitochondrial Membrane Potential

H Ito, Y Shoji, K Matsumoto, K Fukuhara… - ACS Medicinal …, 2023 - ACS Publications
Catechin is one of the best-known antioxidants and is reported to have some favorable
physiological activities, including anti-cancer effects. We previously synthesized a catechin …

Spontaneous rupture of the thoracic aorta

H Yokoyama, M Ohmi, M Sadahiro, Y Shoji… - The Annals of thoracic …, 2000 - Elsevier
Background. Spontaneous rupture of the thoracic aorta without trauma, aneurysm, or dissection
is an extremely rare but catastrophic disorder. Two cases of spontaneous aortic rupture …