HIF-1α, an essential transcription factor under hypoxic condition, is indispensable for
chondrocytes during skeletal development but its expression and roles in articular chondrocytes …

To overcome clinical issues caused by large bone defects and subsequent nonunion, various
approaches to bone regeneration have been researched, including tissue engineering, …

Osteoarthritis (OA) results from an imbalance of the dynamic equilibrium between the breakdown
and repair of joint tissues. Previously, we reported that Runx1 enhanced chondrogenic …

Activation of NF-κB signaling promotes osteoarthritis (OA) through the transcriptional induction
of Hif-2α and catabolic enzymes. This study sought to examine whether inhibiting IκBα …

Lubricin encoded by the proteoglycan 4 (Prg4) gene is produced from superficial zone (SFZ)
cells of articular cartilage and synoviocytes, which is indispensable for lubrication of joint …

Purpose: A clinical feature of myxofibrosarcoma is local recurrence, but knowledge about
distant metastasis is sparse. We evaluated the tendency of clinical and histological features of …

Background The aim of the present study was to evaluate the prevalence of non-ossifying
fibroma (NOF) and fibrous cortical defect (FCD) in a Japanese pediatric population and the …

To overcome serious clinical problems caused by large bone defects, various approaches to
bone regeneration have been researched, including tissue engineering, biomaterials, stem …

A 37-year-old man developed right ankle pain and swelling six days after being diagnosed
with coronavirus disease (COVID-19). Despite conservative treatment, his ankle symptoms …

Objective Transient receptor potential vanilloid channel 2 (TRPV2) is a Ca 2+ ‐permeable
channel and plays a role in mediating intracellular Ca 2+ current via mechanical stimuli. This …