Wnt and Notch signaling have long been established as strongly oncogenic in the mouse
mammary gland. Aberrant expression of several Wnts and other components of this pathway in …

Little is known about the regulation and function of the Notch1 gene in negative control of
human tumors. Here we show that Notch1 gene expression and activity are substantially down-…

: A new culture model was developed to study the role of proliferation and apoptosis in the
etiology of keloids. Fibroblasts were isolated from the superficial, central, and basal regions of …

Background: After major burns, patients can develop nutritional deficiencies including trace
element (TE) deficiencies. Various complications, such as infections and delayed wound …

It is currently unclear whether tissue changes surrounding multifocal epithelial tumors are a
cause or consequence of cancer. Here, we provide evidence that loss of mesenchymal Notch…

Estrogens and progesterones are major drivers of breast development but also promote
carcinogenesis in this organ. Yet, their respective roles and the mechanisms underlying their …

Seventy-five percent of breast cancers are estrogen receptor α positive (ER + ). Research
on these tumors is hampered by lack of adequate in vivo models; cell line xenografts require …

The anterolateral thigh flap based on the descending branch of the lateral circumflex
femoral vessel is one of the musculocutaneous or septocutaneous flaps in the thigh. The …

Introduction Nosocomial pneumonia is a major source of morbidity and mortality after severe
burns. Burned patients suffer trace element deficiencies and depressed antioxidant and …

Myoelectric prostheses allow users to recover lost functionality by controlling a robotic device
with their remaining muscle activity. Such commercial devices can give users a high level …