Purpose Capecitabine is a prodrug that undergoes metabolism in three steps to form an
active 5-fluorouracil (5-FU). The first step is primarily catalyzed by liver carboxylesterases (CES) …

There are several reports on the correlation between early tumor shrinkage (ETS) or depth of
response (DpR) and survival in chemotherapies for colorectal cancer; however, few studies …

A man in his early thirties presented to our clinic with right lower abdominal pain. Computed
tomography (CT) and ultrasonography (US) revealed a swollen appendix and an …

404 Background: FOLFIRINOX, a combination chemotherapy of 5-FU, oxaliplatin, and irinotecan,
has contributed to the overall survival (OS) benefit of advanced pancreatic cancer (PC), …

Background/Aim: If VEGF inhibitors contribute to an increase in D-dimer levels, they may
adversely affect the diagnosis of venous thromboembolism (VTE). Consequently, this …

Clinicians often encounter cases of pulmonary lymphangitic carcinomatosis when treating
patients with cancer. When such a condition develops before the diagnosis of cancer, its …

610 Background: Systemic chemotherapies can convert irresectable liver metastases (LM)
to resectable in some cases of metastatic colorectal cancer (mCRC). Secondary surgical …

237 Background: Results from the phase III PRODIGE 4/ACCORD 11 trial provided one of
current standard regimens for advanced pancreatic cancer (PC), consisting of oxaliplatin, …

Introduction Neuroendocrine tumors (NETs) of the appendix are rare and are often discovered
incidentally during surgery for acute appendicitis or other unrelated conditions (Modlin et …

… Ikusue, Toshikazu P-336 … Moriwaki, Toshikazu O-012 …