Background Alectinib, a potent, highly selective, CNS-active inhibitor of anaplastic lymphoma
kinase (ALK), showed promising efficacy and tolerability in the single-arm phase 1/2 AF-…

Background Patients with non-small-cell lung cancer (NSCLC) and ALK rearrangements
generally have a progression-free survival of 8–11 months while on treatment with the ALK …

Background Currently, crizotinib is the only drug that has been approved for treatment of
ALK-rearranged non-small-cell lung cancer (NSCLC). We aimed to study the activity and safety …

Unilamellar titania crystallites of Ti 1- δ O 2 4 δ - (δ = 0.0875) and polydiallyldimethylammonium
chloride have been alternately deposited layer-by-layer onto various substrates from …

THE LIM homeodomain (LIM-HD) proteins, which contain two tandem LIM domains followed
by a homeodomain, are critical transcriptional regulators of embryonic development 1–5 . …

An increase in the aging population is an impending problem. A large cohort study was
carried out to determine the influence of aging and other factors on hepatocarcinogenesis in …

Background: Lack of leptin is implicated in insulin resistance and other metabolic abnormalities
in generalized lipodystrophy; however, the efficacy, safety, and underlying mechanisms …

This paper reports on the synthesis and characterization of oversized titania nanosheets
derived from single crystals of a potassium lithium titanate, K 0.8 Ti 1.73 Li 0.27 O 4 . The single …

Microbiologists have been using agar growth medium for over 120 years. It revolutionized
microbiology in the 1890s when microbiologists were seeking effective methods to isolate …

α-Klotho (α-Kl) and its homolog, β-Klotho (β-Kl) are key regulators of mineral homeostasis
and bile acid/cholesterol metabolism, respectively. FGF15/ humanFGF19, FGF21, and FGF23, …