User profiles for TATSUHIKO TSUNODA

Tatsuhiko Tsunoda

Professor, The University of Tokyo
Verified email at bs.su-tokyo.ac.jp
Cited by 78405

The international HapMap project

…, M Xiao, A Sekine, K Sorimachi, Y Tanaka, T Tsunoda… - 2003 - deepblue.lib.umich.edu
The goal of the International HapMap Project is to determine the common patterns of DNA
sequence variation in the human genome and to make this information freely available in the …

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

…, Y Hirota, C Ito, M Kubo, T Kawaguchi, T Tsunoda… - Nature …, 2009 - nature.com
To identify susceptibility variants for Parkinson's disease (PD), we performed a genome-wide
association study (GWAS) and two replication studies in a total of 2,011 cases and 18,381 …

Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis

…, A Sekine, A Iida, A Takahashi, T Tsunoda… - Nature …, 2003 - nature.com
Individuals with rheumatoid arthritis frequently have autoantibodies to citrullinated peptides,
suggesting the involvement of the peptidylarginine deiminases citrullinating enzymes (…

Functional SNPs in the lymphotoxin-α gene that are associated with susceptibility to myocardial infarction

…, Y Ohnishi, A Iida, A Sekine, R Yamada, T Tsunoda… - Nature …, 2002 - nature.com
By means of a large-scale, case-control association study using 92,788 gene-based single-nucleotide
polymorphism (SNP) markers, we identified a candidate locus on chromosome …

Integrated molecular analysis of clear-cell renal cell carcinoma

…, K Chiba, H Tanaka, A Niida, A Fujimoto, T Tsunoda… - Nature …, 2013 - nature.com
Clear-cell renal cell carcinoma (ccRCC) is the most prevalent kidney cancer and its molecular
pathogenesis is incompletely understood. Here we report an integrated molecular study of …

Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators

…, S Miyano, H Nakagama, Y Nakamura, T Tsunoda… - Nature …, 2012 - nature.com
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death
worldwide. We sequenced and analyzed the whole genomes of 27 HCCs, 25 of which were …

SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

…, T Lauritzen, T Hansen, S Nurbaya, T Tsunoda… - Nature …, 2008 - nature.com
We conducted a genome-wide association study using 207,097 SNP markers in Japanese
individuals with type 2 diabetes and unrelated controls, and identified KCNQ1 (potassium …

[PDF][PDF] Toward information extraction: identifying protein names from biological papers

K Fukuda, T Tsunoda, A Tamura, T Takagi - Pac symp biocomput, 1998 - psb.stanford.edu
To solve the mystery of the life phenomenon, we must clarify when genes are expressed and
how their products interact with each other. But since the amount of continuously updated …

An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis

…, A Sekine, S Saito, A Takahashi, T Tsunoda… - Nature …, 2003 - nature.com
Rheumatoid arthritis is a common inflammatory disease with complex genetic components.
We investigated the genetic contribution of the cytokine gene cluster in chromosome 5q31 to …

Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and …

…, O Kitahara, R Yanagawa, Y Yamaoka, T Tsunoda… - Cancer research, 2001 - AACR
To disclose detailed genetic mechanisms in hepatocellular carcinoma (HCC) with a view
toward development of novel therapeutic targets, we analyzed expression profiles of 20 …