Patient age is significantly related to the progression of papillary microcarcinoma of the thyroid under observation

Y Ito, A Miyauchi, M Kihara, T Higashiyama… - Thyroid, 2014 - liebertpub.com
Background: We showed previously that subclinical low-risk papillary thyroid microcarcinoma
(PTMC) could be observed without immediate surgery. Patient age is an important …

An observational trial for papillary thyroid microcarcinoma in Japanese patients

…, M Fukushima, M Kihara, T Higashiyama… - World journal of …, 2010 - Wiley Online Library
Background The recent development and spread of ultrasonography and ultrasonography‐guided
fine needle aspiration biopsy (FNAB) has facilitated the detection of small papillary …

Incidences of unfavorable events in the management of low-risk papillary microcarcinoma of the thyroid by active surveillance versus immediate surgery

…, H Masuoka, T Yabuta, M Fukushima, T Higashiyama… - Thyroid, 2016 - liebertpub.com
Background: The incidence of papillary microcarcinoma (PMC) of the thyroid is rapidly
increasing globally, making the management of PMC an important clinical issue. Excellent …

Prognostic impact of serum thyroglobulin doubling-time under thyrotropin suppression in patients with papillary thyroid carcinoma who underwent total thyroidectomy

…, K Kobayashi, Y Ito, Y Takamura, T Higashiyama… - Thyroid, 2011 - liebertpub.com
Background: Detectable serum thyroglobulin (Tg) in patients with papillary thyroid carcinoma
(PTC) after total thyroidectomy implies unsuccessful surgery, indicating a high risk of …

Risk factors for recurrence to the lymph node in papillary thyroid carcinoma patients without preoperatively detectable lateral node metastasis: validity of prophylactic …

Y Ito, T Higashiyama, Y Takamura, A Miya… - World journal of …, 2007 - Springer
Background Although papillary carcinoma usually shows mild characteristics, it metastasizes
and shows recurrence to the lymph node in high incidences. Of the two representative …

BRAF mutation in papillary thyroid carcinoma in a Japanese population: its lack of correlation with high-risk clinicopathological features and disease-free survival of …

…, C Tomoda, M Kihara, T Uruno, T Higashiyama… - Endocrine …, 2009 - jstage.jst.go.jp
Recent studies have demonstrated that BRAFV600E mutation is a common event in
papillary thyroid carcinoma and a majority of these lesions have shown a direct relationship …

[HTML][HTML] Overall survival of papillary thyroid carcinoma patients: a single-institution long-term follow-up of 5897 patients

…, M Kihara, M Fukushima, T Higashiyama… - World journal of …, 2018 - Springer
Introduction Papillary thyroid carcinoma (PTC) generally shows an excellent prognosis except
in cases with aggressive backgrounds or clinicopathological features. Although the cause-…

Clinical significance of lymph node metastasis of thyroid papillary carcinoma located in one lobe

Y Ito, T Jikuzono, T Higashiyama, S Asahi… - World Journal of …, 2006 - Wiley Online Library
Background Previous studies have shown that lymph node metastasis can be of prognostic
value. In this study, we investigated the clinical significance of node metastasis focusing on …

[HTML][HTML] Estimation of the lifetime probability of disease progression of papillary microcarcinoma of the thyroid during active surveillance

…, T Kudo, Y Ito, H Oda, H Sasai, T Higashiyama… - Surgery, 2018 - Elsevier
Background We reported that a minority of patients with low-risk papillary microcarcinoma of
the thyroid showed disease progression during active surveillance and that older patients …

Induction chemotherapy with weekly paclitaxel administration for anaplastic thyroid carcinoma

T Higashiyama, Y Ito, M Hirokawa, M Fukushima… - Thyroid, 2010 - liebertpub.com
Background: Anaplastic thyroid carcinoma (ATC) has a very dire prognosis and no effective
therapeutic strategies have been established for ATC patients, especially those with stage …