Foxp3-expressing CD25 + CD4 + regulatory T cells (Tregs) are abundant in tumor tissues.
Here, hypothesizing that tumor Tregs would clonally expand after they are activated by tumor-…

These results suggest that intestinal bacteria, acting through short-chain fatty acids, regulate
systemic and local prostate IGF1 in the host, which can promote proliferation of prostate …

Purpose: High-fat diet (HFD) could induce prostate cancer progression. The aim of this
study is to identify mechanisms of HFD-induced prostate cancer progression, focusing on …

Bone metastasis (BM) may occur in any type of cancer. The diagnosis of patients with BM
has increased due to improved imaging technologies and advances in cancer drug therapy …

Immune checkpoint inhibitors produce modest responses in metastatic breast cancer, however,
combination approaches may improve responses. A single arm pilot study was designed …

Purpose: Current evolution of cancer immunotherapies, such as immune checkpoint blockade,
has implicated neoantigens as major targets of anticancer cytotoxic T cells. Adoptive T-…

Enfortumab vedotin is a novel antibody–drug conjugate targeting Nectin-4, which is highly
expressed in urothelial carcinoma. However, the expression status of Nectin-4 in upper tract …

Background: We aimed to clarify the clinical significance of TOPK (T-lymphokine–activated
killer cell–originated protein kinase) expression in ovarian cancer and evaluate the possible …

Reliable biomarkers for renal cell carcinoma (RCC) have yet to be determined. Circulating
tumor DNA (ctDNA) is an emerging resource to detect and monitor molecular characteristics …

Most upper tract urothelial carcinomas ( UTUC ) are muscle invasive at the time of diagnosis.
Current standard methods for the diagnosis of UTUC are invasive. Urine cytology is the …