Thorough investigation of a neuronal population can help reveal key aspects regarding the
nervous system and its development. The retinal horizontal cells have several extraordinary …

PMEL is an amyloidogenic protein that appears to be exclusively expressed in pigment
cells and forms intralumenal fibrils within early stage melanosomes upon which eumelanins …

Glial cell line-derived neurotrophic factor (GDNF)/Ret signaling has potent trophic effects on
ventral midbrain dopaminergic, motor, sensory, and sympathetic neurons. The molecular …

Understanding the complete immune cell composition of human neuroblastoma (NB) is
crucial for the development of immunotherapeutics. Here, we perform single-cell RNA …

Nerve Growth Factor (NGF)-induced neuronal differentiation requires the activation of members
of the Rho family of small GTPases. However, the molecular mechanisms through which …

Nociceptin/orphanin FQ (N/OFQ), the nociceptin opioid peptide (NOP) receptor ligand, increases
feeding when injected centrally. Initial data suggest that N/OFQ blocks the development …

Most chemotherapeutics target DNA integrity and thereby trigger tumour cell death through
activation of DNA damage responses that are tightly coupled to the cell cycle. Disturbances …

GABA is more than the main inhibitory neurotransmitter found in the adult CNS. Several studies
have shown that GABA regulates the proliferation of progenitor and stem cells. This work …

Retinal progenitor cells undergo apical mitoses during the process of interkinetic nuclear
migration and newly generated post-mitotic neurons migrate to their prospective retinal layer. …

For proper development, cells need to coordinate proliferation and cell cycle-exit. This is
mediated by a cascade of proteins making sure that each phase of the cell cycle is controlled …