The putative α-secretase cleaves the amyloid precursor protein (APP) of Alzheimer’s
disease in the middle of the amyloid β peptide (Aβ) domain. It is generally thought that the α-…

Several chemically defined plant extracts were investigated for their antiviral action on
herpes simplex virus (HSV-1, HSV-2)-infected African green monkey kidney cells and human …

We describe here the characterization of the so far identified human DNase I family DNases,
DNase I, DNase X, DNase γ, and DNAS1L2. The DNase I family genes are found to be …

Among 87 chemically defined tannins and related compounds, several hydrolyzable tannins,
but not condensed tannins or other lower molecular weight polyphenols, significantly …

Protein kinase C (PKC)-related cDNA clones isolated from cDNA libraries of mouse P19
embryonal carcinoma cells and mouse brain encoded a 67-kDa protein, PKC lambda. PKC …

Based on the DNA fragmentation profile in gel electrophoresis and the morphological changes
in electron microscopy, the induction of apoptotic nuclear changes by mycotoxins and …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation
of amyloid plaques and neurofibrillary tangles in the brain. The major component of the …

Tannins and lignins are natural compounds contained in plants such as tea leaves. Previously,
we demonstrated that tannic acid represses 12-o-tetra-decanoyl phorbol-13-acetate (TPA…

Analyses of cleavage ends of DNA fragments in apoptotic rat thymocytes induced by γ‐ray
irradiation or by treatment with dexamethasone revealed that in both cases the fragments …

Glyoxalase I (GLO I) is the rate-limiting enzyme for detoxification of methylglyoxal (MG), a side
product of glycolysis, which is able to induce apoptosis. Since GLO I is known to be highly …