Background Uveal melanoma is a disease that is distinct from cutaneous melanoma, with a
low tumor mutational burden and a 1-year overall survival of approximately 50% in patients …

Relapse remains a leading cause of death after allogeneic hematopoietic cell transplantation
(HCT) for patients with high-risk leukemias. The potentially beneficial donor T cell–…

Background Tebentafusp, a T-cell receptor–bispecific molecule that targets glycoprotein
100 and CD3, is approved for adult patients who are positive for HLA-A*02:01 and have …

Background Results from a phase 2 trial of the TPEx chemotherapy regimen (docetaxel–platinum–cetuximab)
showed promising results, with a median overall survival of 14·0 months in …

Background Phosphatidylinositol 3-kinase (PI3K) pathway activation in squamous cell
carcinoma of the head and neck contributes to treatment resistance and disease progression. …

Systemic pan-tumor analyses may reveal the significance of common features implicated in
cancer immunogenicity and patient survival. Here, we provide a comprehensive multi-omics …

Multilocus enzyme electrophoresis (MLEE) is the gold standard for taxonomy and strain
typing of Leishmania, but has some limitations. An alternative reliable and fast genotyping …

The Leishmania donovani complex, which consists of L. donovani, L. infantum-L. chagasi,
and L. archibaldi, is responsible for visceral manifestations of leishmaniasis. Multilocus …

Patients with Philadelphia chromosome-negative myeloproliferative neoplasms (MPN) like
polycythemia vera and essential thrombocythemia are at increased risk of arterial and …

Background Leishmania infantum is the causative agent of visceral and cutaneous
leishmaniasis in the Mediterranean region, South America, and China. MON-1 L. infantum is the …