Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell …
SFM Häusler, I Montalbán del Barrio… - Cancer Immunology …, 2011 - Springer
The ectonucleotidases CD39 and CD73 degrade immune stimulatory ATP to adenosine
that inhibits T and NK cell responses via the A 2A adenosine receptor (ADORA2A). This …
that inhibits T and NK cell responses via the A 2A adenosine receptor (ADORA2A). This …
Macrophage migration inhibitory factor contributes to the immune escape of ovarian cancer by down-regulating NKG2D
M Krockenberger, Y Dombrowski, C Weidler… - The Journal of …, 2008 - journals.aai.org
The proinflammatory cytokine macrophage migration inhibitory factor (MIF) stimulates tumor
cell proliferation, migration, and metastasis; promotes tumor angiogenesis; suppresses p53-…
cell proliferation, migration, and metastasis; promotes tumor angiogenesis; suppresses p53-…
[HTML][HTML] Anti-CD39 and anti-CD73 antibodies A1 and 7G2 improve targeted therapy in ovarian cancer by blocking adenosine-dependent immune evasion
SFM Häusler, IM Del Barrio, J Diessner… - American journal of …, 2014 - ncbi.nlm.nih.gov
The ectonucleotidases CD39 and CD73 degrade ATP to adenosine which inhibits immune
responses via the A 2A adenosine receptor (ADORA2A) on T and NK cells. The current study …
responses via the A 2A adenosine receptor (ADORA2A) on T and NK cells. The current study …
Immunoselection of Breast and Ovarian Cancer Cells with Trastuzumab and Natural Killer Cells: Selective Escape of CD44high/CD24low/HER2low Breast Cancer …
F Reim, Y Dombrowski, C Ritter, M Buttmann… - Cancer research, 2009 - AACR
Although trastuzumab (Herceptin) has substantially improved the overall survival of patients
with mammary carcinomas, even initially well-responding tumors often become resistant. …
with mammary carcinomas, even initially well-responding tumors often become resistant. …
[HTML][HTML] Adenosine-generating ovarian cancer cells attract myeloid cells which differentiate into adenosine-generating tumor associated macrophages–a self …
…, M Mittelbronn, J Wischhusen, SFM Häusler - … for immunotherapy of …, 2016 - Springer
Background Ovarian cancer (OvCA) tissues show abundant expression of the ectonucleotidases
CD39 and CD73 which generate immunomodulatory adenosine, thereby inhibiting …
CD39 and CD73 which generate immunomodulatory adenosine, thereby inhibiting …
Immune response to SARS-CoV-2 in health care workers following a COVID-19 outbreak: a prospective longitudinal study
…, R Gruber, A Ambrosch, M Kabesch, S Häusler - Journal of Clinical …, 2020 - Elsevier
Objective Currently, little is known about the progression of an immune response against
SARSCoV- 2 upon infection or sub-infection-exposure over time. We examined the serologic …
SARSCoV- 2 upon infection or sub-infection-exposure over time. We examined the serologic …
Successful containment of Covid‐19 outbreak in a large maternity and perinatal center while continuing clinical service
…, S Roth, S Brandstetter, S Häusler… - Pediatric Allergy and …, 2020 - Wiley Online Library
With increasing number of SARS‐CoV‐2 infections and COVID‐19 patients to be taken care
of by the health system, more and more health workers become affected by the disease. It …
of by the health system, more and more health workers become affected by the disease. It …
[HTML][HTML] Evaluation of clinical parameters influencing the development of bone metastasis in breast cancer
…, T Stüber, R Stein, M Krockenberger, S Häusler… - BMC cancer, 2016 - Springer
Background The development of metastases is a negative prognostic parameter for the
clinical outcome of breast cancer. Bone constitutes the first site of distant metastases for many …
clinical outcome of breast cancer. Bone constitutes the first site of distant metastases for many …
[HTML][HTML] Micro-ribonucleic acids and extracellular vesicles repertoire in the spent culture media is altered in women undergoing In Vitro Fertilization
MicroRNAs (miRNAs) are class of small RNA molecules with major impact on gene regulation.
We analyzed the potential of miRNAs secreted from pre-implantation embryos into the …
We analyzed the potential of miRNAs secreted from pre-implantation embryos into the …
Cognate Nonlytic Interactions between CD8+ T Cells and Breast Cancer Cells Induce Cancer Stem Cell–like Properties
…, VJ Thiemann, MP Wustrow, SF Häusler… - Cancer research, 2019 - AACR
This study shows that ineffective immune responses not only fail to clear a malignancy, but
can also activate pathways in cancer cells that promote stemness and tumor-seeding capacity…
can also activate pathways in cancer cells that promote stemness and tumor-seeding capacity…