Endometriosis and cancer

H Kajiyama, S Suzuki, M Yoshihara, S Tamauchi… - Free Radical Biology …, 2019 - Elsevier
Endometriosis, characterized by the presence of extra-uterine endometrium, is a common
gynecologic disorder in reproductive-age women. Although the detailed molecular mechanism …

[HTML][HTML] Reproductive outcomes of 105 malignant ovarian germ cell tumor survivors: a multicenter study

S Tamauchi, H Kajiyama, M Yoshihara, Y Ikeda… - American Journal of …, 2018 - Elsevier
Background Malignant ovarian germ cell tumors usually occur in young women. Until the
1970s, before establishment of systemic chemotherapy, malignant ovarian germ cell tumors …

[HTML][HTML] Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination via blockade of the TGF-β1/thrombospondin-1 axis

K Kitami, M Yoshihara, S Tamauchi, M Sugiyama… - Matrix Biology, 2022 - Elsevier
Ovarian cancer (OvCa), a lethal gynecological malignancy, disseminates to the peritoneum.
Mesothelial cells (MCs) act as barriers in the abdominal cavity, preventing the adhesion of …

CCL2 secreted from cancer-associated mesothelial cells promotes peritoneal metastasis of ovarian cancer cells through the P38-MAPK pathway

H Yasui, H Kajiyama, S Tamauchi, S Suzuki… - Clinical & Experimental …, 2020 - Springer
Epithelial ovarian cancer (EOC) is considered to secrete various factors in order to promote
peritoneal dissemination through cell-to-cell interaction between cancer and mesothelial …

Efficacy of medroxyprogesterone acetate treatment and retreatment for atypical endometrial hyperplasia and endometrial cancer

S Tamauchi, H Kajiyama, F Utsumi… - Journal of Obstetrics …, 2018 - Wiley Online Library
Aim Medroxyprogesterone acetate ( MPA ) is used to preserve fertility in patients with G
rade 1 endometrial cancer without myometrial invasion ( G1EA ) and those with atypical …

[HTML][HTML] Prognostic factors and effects of fertility-sparing surgery in women of reproductive age with ovarian clear-cell carcinoma: a propensity score analysis

M Yoshihara, H Kajiyama, S Tamauchi… - Journal of …, 2019 - ncbi.nlm.nih.gov
Objective The aim of this study was to investigate the clinical characteristics of young patients
with stage I clear-cell carcinoma (CCC) and evaluate the prognostic factors and effects of …

[HTML][HTML] Hypoalbuminemia for the prediction of survival in patients with stage IVB cervical cancer

N Yoshikawa, M Yoshihara, S Tamauchi, Y Ikeda… - Plos one, 2022 - journals.plos.org
We evaluated the prognostic significance of malnutrition in patients with metastatic cervical
cancer. In this study, we retrospectively analyzed the cases of 43 patients with stage IVB (…

[HTML][HTML] Novel therapeutic strategies targeting UCP2 in uterine leiomyosarcoma

…, Y Koya, M Yoshihara, S Tamauchi… - Pharmacological …, 2023 - Elsevier
Uterine leiomyosarcoma (ULMS) is a malignant stromal tumor arising from the myometrium
with a poor prognosis and very limited response to current chemotherapy. This study aimed …

Oncologic and obstetric outcomes of early stage cervical cancer with abdominal radical trachelectomy: Single‐institution experience

S Tamauchi, H Kajiyama, J Sakata… - Journal of Obstetrics …, 2016 - Wiley Online Library
Aim Radical trachelectomy (RT) is a widely used fertility‐sparing treatment for patients with
early cervical cancer (CCA). RT, however, is an investigational treatment, and its …

[HTML][HTML] Expression of the chrXq27. 3 miRNA cluster in recurrent ovarian clear cell carcinoma and its impact on cisplatin resistance

…, A Yokoi, M Sugiyama, S Oda, K Kitami, S Tamauchi… - Oncogene, 2021 - nature.com
Ovarian clear cell carcinoma (OCCC) is a histological subtype of epithelial ovarian cancer
and exhibits dismal prognosis due to chemoresistance. Moreover, only few effective …