NBTXR3, a first-in-class radioenhancer hafnium oxide nanoparticle, plus radiotherapy versus radiotherapy alone in patients with locally advanced soft-tissue sarcoma …

…, E Saada-Bouzid, A Borkowska, R Anghel… - The Lancet …, 2019 - thelancet.com
Background Pathological complete response to preoperative treatment in adults with soft-tissue
sarcoma can be achieved in only a few patients receiving radiotherapy. This phase 2–3 …

Bevacizumab plus paclitaxel versus bevacizumab plus capecitabine as first-line treatment for HER2-negative metastatic breast cancer (TURANDOT): primary endpoint …

…, A Eniu, B Nisenbaum, M Dank, R Anghel… - The Lancet …, 2016 - thelancet.com
Background The randomised phase 3 TURANDOT trial compared two approved
bevacizumab-containing regimens for HER2-negative metastatic breast cancer in terms of efficacy, …

A randomized phase II trial (TAMIGA) evaluating the efficacy and safety of continuous bevacizumab through multiple lines of treatment for recurrent glioblastoma

…, G Fountzilas, DM Cernea, O Chinot, R Anghel… - The …, 2019 - academic.oup.com
Background We assessed the efficacy and safety of bevacizumab (BEV) through multiple
lines in patients with recurrent glioblastoma who had progressed after first‐line treatment with …

[HTML][HTML] Relationship between tumor infiltrating lymphocytes and progression in breast cancer

A Zgura, L Galesa, E Bratila, R Anghel - Maedica, 2018 - ncbi.nlm.nih.gov
The immune system is very critical in suppression of cancer development. The composition
of breast cancer-infiltrating lymphocytes has been widely investigated so far and it is …

[HTML][HTML] Assessing the spleen as an organ at risk in radiation therapy and its relationship with radiation-induced lymphopenia: a retrospective study and literature …

M Alexandru, A Rodica, G Dragos-Eugen… - Advances in Radiation …, 2021 - Elsevier
Purpose We conducted a systematic review and a retrospective study to investigate the
relationship between spleen irradiation and lymphocyte toxicity. Methods and Materials Forty-six …

[HTML][HTML] Quantitative Analysis of SPECT-CT Data in Metastatic Breast Cancer Patients—The Clinical Significance

…, I Irimescu, A Lazar, X Bacinschi, RM Anghel - Cancers, 2022 - mdpi.com
Simple Summary Breast cancer represents one of the most common cancers diagnosed in
female patients, with up to 75% of the patients with stage IV breast cancer developing …

[HTML][HTML] Antidiabetics, anthelmintics, statins, and beta-blockers as co-adjuvant drugs in cancer therapy

…, R Mitrica, M Georgescu, O Trifanescu, R Anghel… - Medicina, 2022 - mdpi.com
Over the last years, repurposed agents have provided growing evidence of fast implementation
in oncology treatment such as certain antimalarial, anthelmintic, antibiotics, anti-…

Impact of the COVID-19 pandemic on treatment and oncologic outcomes for cancer patients in Romania

…, M Georgescu, A Sandu, A Michire, R Anghel - in vivo, 2022 - iv.iiarjournals.org
Background/Aim: This study aimed to assess the impact of the ongoing COVID-19
pandemic on cancer patients, known to be immune-compromised due to the disease itself, …

[HTML][HTML] Final safety and health-related quality of LIfe results of the Phase 2/3 Act. In. Sarc Study with Preoperative NBTXR3 Plus Radiation Therapy Versus Radiation …

…, S Helfre, E Saada-Bouzid, RM Anghel… - International Journal of …, 2022 - Elsevier
Purpose Act.In.Sarc (NCT02379845) demonstrated that the first-in-class radioenhancer
NBTXR3, activated by preoperative radiation therapy (RT), doubled the rate of pathologic …

[HTML][HTML] Quantitative Assessment of Treatment Response in Metastatic Breast Cancer Patients by SPECT-CT Bone Imaging—Getting Closer to PET-CT

…, AM Lazar, RV Toma, OG Trifanescu, RM Anghel - Cancers, 2023 - mdpi.com
Simple Summary The aim of our study is to demonstrate the added value of the quantitative
interpretation of SPECT-CT images compared to qualitative assessment regarding changes …