Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR) combining anti-EGFR antibody with tyrosine kinase inhibitor
S Huang, EA Armstrong, S Benavente, P Chinnaiyan… - Cancer research, 2004 - AACR
Molecular inhibition of epidermal growth factor receptor (EGFR/HER1) signaling is under
active investigation as a promising cancer treatment strategy. We examined the potency of …
active investigation as a promising cancer treatment strategy. We examined the potency of …
The metabolomic signature of malignant glioma reflects accelerated anabolic metabolism
P Chinnaiyan, E Kensicki, G Bloom, A Prabhu, B Sarcar… - Cancer research, 2012 - AACR
Although considerable progress has been made toward understanding glioblastoma biology
through large-scale genetic and protein expression analyses, little is known about the …
through large-scale genetic and protein expression analyses, little is known about the …
Cysteine catabolism: a novel metabolic pathway contributing to glioblastoma growth
…, JJ Johnson, KP Adam, E Kensicki, P Chinnaiyan - Cancer research, 2014 - AACR
The relevance of cysteine metabolism in cancer has gained considerable interest in recent
years, largely focusing on its role in generating the antioxidant glutathione. Through …
years, largely focusing on its role in generating the antioxidant glutathione. Through …
Mechanisms of enhanced radiation response following epidermal growth factor receptor signaling inhibition by erlotinib (Tarceva)
P Chinnaiyan, S Huang, G Vallabhaneni, E Armstrong… - Cancer research, 2005 - AACR
Erlotinib (Tarceva) is an orally available HER1 (epidermal growth factor receptor, EGFR)
tyrosine kinase inhibitor advancing through clinical trials for the treatment of a range of human …
tyrosine kinase inhibitor advancing through clinical trials for the treatment of a range of human …
The impact of daily setup variations on head-and-neck intensity-modulated radiation therapy
PURPOSE: Intensity-modulated radiation therapy (IMRT) in the treatment of head-and-neck (H&N)
cancer provides the opportunity to diminish normal tissue toxicity profiles and thereby …
cancer provides the opportunity to diminish normal tissue toxicity profiles and thereby …
[PDF][PDF] Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors
Purpose Aberrant Notch signaling has been implicated in the pathogenesis of many human
cancers. MK-0752 is a potent, oral inhibitor of-secretase, an enzyme required for Notch …
cancers. MK-0752 is a potent, oral inhibitor of-secretase, an enzyme required for Notch …
Modulation of radiation response by histone deacetylase inhibition
P Chinnaiyan, G Vallabhaneni, E Armstrong… - International Journal of …, 2005 - Elsevier
Purpose: Histone deacetylase (HDAC) inhibitors, which modulate chromatin structure and
gene expression, represent a class of anticancer agents that hold particular potential as …
gene expression, represent a class of anticancer agents that hold particular potential as …
[HTML][HTML] Whole brain radiotherapy for brain metastasis
E McTyre, J Scott, P Chinnaiyan - Surgical neurology international, 2013 - ncbi.nlm.nih.gov
Whole brain radiotherapy (WBRT) is a mainstay of treatment in patients with both identifiable
brain metastases and prophylaxis for microscopic disease. The use of WBRT has …
brain metastases and prophylaxis for microscopic disease. The use of WBRT has …
A randomized phase II study of everolimus in combination with chemoradiation in newly diagnosed glioblastoma: results of NRG Oncology RTOG 0913
P Chinnaiyan, M Won, PY Wen, AM Rojiani… - Neuro …, 2018 - academic.oup.com
Background This phase II study was designed to determine the efficacy of the mammalian
target of rapamycin (mTOR) inhibitor everolimus administered daily with conventional …
target of rapamycin (mTOR) inhibitor everolimus administered daily with conventional …
[HTML][HTML] The radiosensitivity index predicts for overall survival in glioblastoma
We have previously developed a multigene expression model of tumor radiosensitivity (RSI)
with clinical validation in multiple cohorts and disease sites. We hypothesized RSI would …
with clinical validation in multiple cohorts and disease sites. We hypothesized RSI would …