User profiles for PASQUALE CHIECO

Pasquale Chieco

Adjunct professor University of Bologna
Verified email at unibo.it
Cited by 6858

[HTML][HTML] IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland

…, P Paterini, KB Marcu, P Chieco… - The Journal of …, 2007 - Am Soc Clin Investig
High serum levels of IL-6 correlate with poor outcome in breast cancer patients. However,
no data are available on the relationship between IL-6 and mammary stem/progenitor cells, …

MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells

…, GA Calin, GL Grazi, CM Croce, S Tavolari, P Chieco… - Cancer research, 2009 - AACR
The identification of target genes is a key step for assessing the role of aberrantly expressed
microRNAs (miRNA) in human cancer and for the further development of miRNA-based …

MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells

F Fornari, M Milazzo, P Chieco, M Negrini, GA Calin… - Cancer research, 2010 - AACR
MicroRNAs (miRNA) have rapidly emerged as modulators of gene expression in cancer in
which they may have great diagnostic and therapeutic import. MicroRNA-199a-3p (miR-199a-…

Nucleolar size indicates the rapidity of cell proliferation in cancer tissues

…, A Pession, M Govoni, V Sirri, P Chieco - The Journal of …, 2000 - Wiley Online Library
In order to define the importance of the nucleolus in tumour pathology, the relationship
between nucleolar size and function and tumour mass growth rate was studied in vivo. Ten …

p66Shc/Notch-3 interplay controls self-renewal and hypoxia survival in human stem/progenitor cells of the mammary gland expanded in vitro as mammospheres

…, M Taffurelli, D Santini, C Ceccarelli, P Chieco… - Stem …, 2007 - academic.oup.com
The comprehension of the basic biology of stem cells is expected to provide a useful insight
into the pathogenesis of cancer. In particular, there is evidence that hypoxia promotes stem …

In hepatocellular carcinoma miR‐519d is up‐regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2

F Fornari, M Milazzo, P Chieco, M Negrini… - The Journal of …, 2012 - Wiley Online Library
MiR‐519d belongs to the chromosome 19 miRNA cluster (C19MC), the largest human miRNA
cluster. One of its members, miR‐519d, is over‐expressed in hepatocellular carcinoma (…

TNFalpha up‐regulates SLUG via the NF‐kappaB/HIF1alpha axis, which imparts breast cancer cells with a stem cell‐like phenotype

…, C Ceccarelli, D Santini, P Chieco… - Journal of cellular …, 2010 - Wiley Online Library
Extracellular and intracellular mediators of inflammation, such as tumor necrosis factor
alpha (TNFα) and NF‐kappaB (NF‐κB), play major roles in breast cancer pathogenesis, …

The basal‐like breast carcinoma phenotype is regulated by SLUG gene expression

…, L Montanaro, D Santini, P Chieco… - The Journal of …, 2008 - Wiley Online Library
Basal‐like breast carcinoma is an aggressive form of breast cancer, characterized by the
absence of oestrogen receptor and HER2 expression, the presence of cytokeratin 5 and …

The Feulgen reaction 75 years on

P Chieco, M Derenzini - Histochemistry and cell biology, 1999 - Springer
The Feulgen reaction proposed by Feulgen and Rossenbeck 75 years ago is one of the
cytohistochemical reactions most widely used in biology and medicine. It allows DNA in situ to …

Increased expression of p16 (INK4a) and p27 (Kip1) cyclin-dependent kinase inhibitor genes in aging human kidney and chronic allograft nephropathy

…, M Yakubovich, J Vienken, S Stefoni, P Chieco… - American journal of …, 2003 - Elsevier
BACKGROUND:: The goal of the current study was to examine the potential value of p16 (INK4a)
and p27 (Kip1) cyclin-dependent kinase inhibitor (CDKI) genes in the process of …