Colorectal cancer (CRC) remains a serious health problem worldwide. Approximately half
of patients will develop distant metastasis after CRC resection, usually with very poor …

Secondary tumors of the ovary account for 10–25% of all ovarian malignancies. The most
common tumors that give rise to ovarian metastases include breast, colorectal, endometrial, …

Despite distant metastases being the critical factor affecting patients' survival, they remain
poorly understood. Our study thus aimed to molecularly characterize colorectal cancer liver …

Background Great progress has recently been made in the treatment of metastatic renal cell
carcinoma, including the introduction of nivolumab, an immune checkpoint inhibitor. Despite …

Infections represent a significant cause of morbidity and mortality in cancer patients. Multiple
factors related to the patient, tumor, and cancer therapy can affect the risk of infection in …

Microsatellite instability (MSI) and mismatch repair deficiency are an emerging issue in
oncology and molecular pathology. Besides being associated with better clinical outcome in …

Immunotherapy has attracted attention as a novel treatment modality for malignant melanoma.
Although the use of immunotherapy in metastatic melanoma has shown promising results, …

Telomeric sequences, the structures comprised of hexanucleotide repeats and associated
proteins, play a pivotal role in chromosome end protection and preservation of genomic …

Recently, new drugs targeting the immune system have been introduced to the standard care
of metastatic malignant melanoma. One of these immunomodulatory drugs is ipilimumab, a …

MUC13, a transmembrane mucin glycoprotein, is overexpressed in colorectal cancer (CRC),
however, its regulation and functions are not fully understood. It has been shown that …