Endothelial pathomechanisms in acute lung injury

NA Maniatis, A Kotanidou, JD Catravas… - Vascular pharmacology, 2008 - Elsevier
Acute lung injury (ALI) and its most severe extreme the acute respiratory distress syndrome (ARDS)
refer to increased-permeability pulmonary edema caused by a variety of pulmonary …

The endothelium in acute lung injury/acute respiratory distress syndrome

NA Maniatis, SE Orfanos - Current opinion in critical care, 2008 - journals.lww.com
Mechanistic studies have delivered several interventions, which are effective in preventing
and treating experimental acute lung injury and have thus provided objectives for …

Novel mechanism of endothelial nitric oxide synthase activation mediated by caveolae internalization in endothelial cells

NA Maniatis, V Brovkovych, SE Allen, TA John… - Circulation …, 2006 - Am Heart Assoc
Caveolin-1, the caveolae scaffolding protein, binds to and negatively regulates eNOS activity.
As caveolin-1 also regulates caveolae-mediated endocytosis after activation of the 60-kDa …

Increased pulmonary vascular resistance and defective pulmonary artery filling in caveolin-1−/− mice

NA Maniatis, V Shinin… - … of Physiology-Lung …, 2008 - journals.physiology.org
Caveolin-1, the structural and signaling protein of caveolae, is an important negative regulator
of endothelial nitric oxide synthase (eNOS). We observed that mice lacking caveolin-1 (…

[HTML][HTML] Static and dynamic mechanics of the murine lung after intratracheal bleomycin

…, A Armaganidis, GT Stathopoulos, NA Maniatis - BMC Pulmonary …, 2011 - Springer
Background Despite its widespread use in pulmonary fibrosis research, the bleomycin mouse
model has not been thoroughly validated from a pulmonary functional standpoint using …

Elevated biomarkers of endothelial dysfunction/activation at ICU admission are associated with sepsis development

…, Z Mastora, SE Orfanos, E Jahaj, NA Maniatis… - Cytokine, 2014 - Elsevier
Widespread endothelial activation and dysfunction often precede clinical sepsis. Several
endothelium-related molecules have been investigated as potential biomarkers for early …

[HTML][HTML] Induced expression and functional effects of aquaporin-1 in human leukocytes in sepsis

AG Vassiliou, NA Maniatis, SE Orfanos, Z Mastora… - Critical care, 2013 - Springer
Introduction Gene expression profiling was performed via DNA microarrays in leukocytes
from critically ill trauma patients nonseptic upon admission to the ICU, who subsequently …

Caveolins and lung function

NA Maniatis, O Chernaya, V Shinin… - Caveolins and Caveolae …, 2012 - Springer
The primary function of the mammalian lung is to facilitate diffusion of oxygen to venous blood
and to ventilate carbon dioxide produced by catabolic reactions within cells. However, it is …

[HTML][HTML] Metformin attenuates ventilator-induced lung injury

G Tsaknis, II Siempos, P Kopterides, NA Maniatis… - Critical Care, 2012 - Springer
Introduction Diabetic patients may develop acute lung injury less often than non-diabetics; a
fact that could be partially ascribed to the usage of antidiabetic drugs, including metformin. …

Differential expression of aquaporins in experimental models of acute lung injury

…, N Manitsopoulos, M Kardara, NA Maniatis… - in vivo, 2017 - iv.iiarjournals.org
Aim: The mammalian lung expresses at least three aquaporin (AQP) water channels whose
precise role in lung injury or inflammation is still controversial. Materials and Methods: Three …