User profiles for NAOKI OKUMURA
 | Naoki OkumuraDoshisha University Verified email at mail.doshisha.ac.jp Cited by 5335 |
PIK3CA Mutations and Copy Number Gains in Human Lung Cancers
…, M Nomura, WW Lockwood, M Sato, N Okumura… - Cancer research, 2008 - AACR
We investigated the frequency and function of mutations and increased copy number of the
PIK3CA gene in lung cancers. PIK3CA mutations are one of the most common gene changes …
PIK3CA gene in lung cancers. PIK3CA mutations are one of the most common gene changes …
[HTML][HTML] Injection of cultured cells with a ROCK inhibitor for bullous keratopathy
Background Corneal endothelial cell (CEC) disorders, such as Fuchs’s endothelial corneal
dystrophy, induce abnormal corneal hydration and result in corneal haziness and vision loss …
dystrophy, induce abnormal corneal hydration and result in corneal haziness and vision loss …
[HTML][HTML] Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells
J Soh, N Okumura, WW Lockwood, H Yamamoto… - PloS one, 2009 - journals.plos.org
Background Activating mutations in one allele of an oncogene (heterozygous mutations)
are widely believed to be sufficient for tumorigenesis. However, mutant allele specific …
are widely believed to be sufficient for tumorigenesis. However, mutant allele specific …
[HTML][HTML] Is conversion therapy possible in stage IV gastric cancer: the proposal of new biological categories of classification
K Yoshida, K Yamaguchi, N Okumura, T Tanahashi… - Gastric cancer, 2016 - Springer
Conversion therapy for gastric cancer (GC) has been the subject of much recent attention. It
is defined as a surgical treatment aiming at an R0 resection after chemotherapy for tumors …
is defined as a surgical treatment aiming at an R0 resection after chemotherapy for tumors …
[HTML][HTML] Enhancement on primate corneal endothelial cell survival in vitro by a ROCK inhibitor
purpose. The transplantation of cultivated corneal endothelial cells (CECs) has gained
attention recently for the treatment of patients with corneal endothelial dysfunction. However, an …
attention recently for the treatment of patients with corneal endothelial dysfunction. However, an …
[HTML][HTML] ROCK inhibitor converts corneal endothelial cells into a phenotype capable of regenerating in vivo endothelial tissue
Corneal endothelial dysfunction accompanied by visual disturbance is a primary indication
for corneal transplantation. We previously reported that the adhesion of corneal endothelial …
for corneal transplantation. We previously reported that the adhesion of corneal endothelial …
[HTML][HTML] Cultivated corneal endothelial cell sheet transplantation in a primate model
purpose. To examine the feasibility of cultivated corneal endothelial cell transplantation in a
primate model. methods. Monkey corneal endothelial cells (MCECs) obtained from three …
primate model. methods. Monkey corneal endothelial cells (MCECs) obtained from three …
[HTML][HTML] The ROCK inhibitor eye drop accelerates corneal endothelium wound healing
Purpose.: To evaluate the effect of Rho kinase (ROCK)-inhibitor eye drops on a corneal
endothelial dysfunction primate model and human clinical case series of corneal endothelial …
endothelial dysfunction primate model and human clinical case series of corneal endothelial …
[HTML][HTML] Inhibition of TGF-β Signaling Enables Human Corneal Endothelial Cell Expansion In Vitro for Use in Regenerative Medicine
N Okumura, EDP Kay, M Nakahara, J Hamuro… - PloS one, 2013 - journals.plos.org
Corneal endothelial dysfunctions occurring in patients with Fuchs' endothelial corneal
dystrophy, pseudoexfoliation syndrome, corneal endotheliitis, and surgically induced corneal …
dystrophy, pseudoexfoliation syndrome, corneal endotheliitis, and surgically induced corneal …
Enhancement of corneal endothelium wound healing by Rho-associated kinase (ROCK) inhibitor eye drops
Aim To demonstrate the efficacy of Rho-associated kinase (ROCK) inhibitor Y-27632 for
corneal endothelial wound healing both in in vitro and in vivo models. Methods As an in vitro …
corneal endothelial wound healing both in in vitro and in vivo models. Methods As an in vitro …