The insulin/insulin-like growth factor (IGF) system is a major determinant in the pathogenesis
and progression of colorectal cancer (CRC). Indeed, several components of this signaling …

Resistance to chemotherapy predicts an unfavorable outcome for patients with radioiodine-insensitive
thyroid cancer. To investigate the mechanisms underlying this resistance, we …

Thyroid cancer comprises different clinical and histological entities. Whereas differentiated (DTCs)
malignancies are sensitive to radioiodine therapy, anaplastic (ATCs) and medullary (…

Thyroid cancers are common endocrine malignancies that comprise tumors with different
clinical and histological features. Indeed, papillary and follicular thyroid cancers are slow-…

Background Extent of tumor resection (EOTR) in glioblastoma surgery plays an important
role in improving survival. Objective To analyze the efficacy, safety and reliability of fluid-…

The introduction of ABL Tyrosine Kinase Inhibitors (TKIs) has significantly improved the
outcome of Chronic Myeloid Leukemia (CML) patients that, in large part, achieve satisfactory …

Simple Summary Gliomas represent a wide group of central nervous system neoplasms,
arising from the glial component of the central nervous system. They are generally sub-…

Patients with thyroid cancers refractory to radioiodine (RAI) treatment show a limited
response to various therapeutic options and a low survival rate. The recent use of multikinase …

Glioblastoma multiforme (GBM) is the most common primary brain malignancy and is often
resistant to conventional treatments due to its extensive cellular heterogeneity. Thus, the …

The management of patients with Central Nervous System (CNS) malignancies relies on
the appropriate classification of these tumors. Recently, the World Health Organization (WHO) …