Improved bacterial identification directly from urine samples with matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry

…, K Onuma, M Nishida, M Fujiwara… - Journal of clinical …, 2018 - Wiley Online Library
Background Matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (
MALDI ‐ TOF MS ) contributes to rapid identification of pathogens in the clinic but has not yet …

Lard-based high-fat diet increases secretory leukocyte protease inhibitor expression and attenuates the inflammatory response of acute lung injury in endotoxemic …

M Fujiwara, M Miyoshi, S Sakai, A Nishiokada… - Clinical nutrition, 2015 - Elsevier
Background & aims Acute lung injury (ALI) is less severe in obese than in nonobese patients,
but the mechanism is unclear. Secretory leukocyte protease inhibitor (SLPI) is the key anti-…

Mild obesity reduces survival and adiponectin sensitivity in endotoxemic rats

S Sakai, N Iizuka, M Fujiwara, M Miyoshi… - journal of surgical …, 2013 - Elsevier
Background Recent meta-analyses have reported that critically ill patients with morbid obesity
(body mass index >40 kg/m 2 ) have poor outcomes, but the effects and mechanisms of …

A lard-rich high-fat diet increases hepatic peroxisome proliferator–activated receptors in endotoxemic rats

M Kai, M Miyoshi, M Fujiwara, Y Nishiyama… - Journal of Surgical …, 2017 - Elsevier
Background Diets high in saturated fatty acids activate chronic inflammation. We previously
reported that, in even acute inflammation caused by lipopolysaccharide (LPS), liver injury …

Oral tributyrin prevents endotoxin-induced lipid metabolism disorder

M Miyoshi, N Iizuka, S Sakai, M Fujiwara… - Clinical nutrition …, 2015 - Elsevier
Background & aims Sepsis leads to dysregulation of lipid and lipoprotein metabolism. Butyrate
increases peroxisome proliferator-activated receptors (PPARs), which are key nuclear …

IL18 production and IL18 promoter polymorphisms correlate with mortality in ICU patients

…, M Aoyama-Ishikawa, H Yamashita, M Fujiwara… - in vivo, 2014 - iv.iiarjournals.org
Background: Single nucleotide polymorphisms in the promoter of interleukin (IL)-18 (-607C/A
and -137G/C) may affect the clinical course of inflammatory diseases. This study examined …

Changes of hepatic lipid mediators associated with intake of high-fat diet for 12 weeks in endotoxemic rats using LC-ESI-MS/MS

A Nishiokada, M Miyoshi, M Fujiwara… - Clinical nutrition, 2015 - Elsevier
Background & aims It has recently been reported that anti-inflammatory lipid mediators are
increased in the late phase of acute inflammation, whereas proinflammatory lipid mediators …

Supplementation of parenteral nutrition with fish oil attenuates acute lung injury in a rat model

…, M Nakayama, H Yamashita, M Fujiwara… - journal of clinical …, 2014 - jstage.jst.go.jp
Fish oil rich in n-3 polyunsaturated fatty acids has diverse immunomodulatory properties
and attenuates acute lung injury when administered in enternal nutrition. However, enteral …

[HTML][HTML] The gilles de la Tourette syndrome-quality of life scale (GTS-QOL): a validation in Japanese patients

…, Y Hamamoto, Y Eriguchi, M Fujiwara… - Frontiers in …, 2022 - frontiersin.org
Background: Though Gilles de la Tourette's syndrome (GTS) has significant impact on the
quality of life of its patients, measures of health-related quality of life (HR-QOL) specific to …

[HTML][HTML] The effects of comorbid Tourette symptoms on distress caused by compulsive-like behavior in very young children: a cross-sectional study

R Goto, M Fujio, N Matsuda, M Fujiwara… - Child and Adolescent …, 2019 - Springer
Background Many children 4 to 6 years old exhibit compulsive-like behavior, often with comorbid
Tourette symptoms, making this age group critical for investigating the effects of having …