Cancer nanotechnology: opportunities and challenges
M Ferrari - Nature reviews cancer, 2005 - nature.com
Nanotechnology is a multidisciplinary field, which covers a vast and diverse array of devices
derived from engineering, biology, physics and chemistry. These devices include …
derived from engineering, biology, physics and chemistry. These devices include …
Principles of nanoparticle design for overcoming biological barriers to drug delivery
E Blanco, H Shen, M Ferrari - Nature biotechnology, 2015 - nature.com
Biological barriers to drug transport prevent successful accumulation of nanotherapeutics
specifically at diseased sites, limiting efficacious responses in disease processes ranging from …
specifically at diseased sites, limiting efficacious responses in disease processes ranging from …
Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications
Many nanosized particulate systems are being developed as intravascular carriers to increase
the levels of therapeutic agents delivered to targets, with the fewest side effects 1 , 2 . The …
the levels of therapeutic agents delivered to targets, with the fewest side effects 1 , 2 . The …
Clinical cancer nanomedicine
J Wolfram, M Ferrari - Nano today, 2019 - Elsevier
Nanotechnology offers new solutions for the development of cancer therapeutics that display
improved efficacy and safety. Although several nanotherapeutics have received clinical …
improved efficacy and safety. Although several nanotherapeutics have received clinical …
[HTML][HTML] Clinical proteomics: written in blood
LA Liotta, M Ferrari, E Petricoin - Nature, 2003 - nature.com
The blood contains a treasure trove of previously unstudied biomarkers that could reflect the
ongoing physiologic state of all tissues. Every cell in the body leaves a record of its …
ongoing physiologic state of all tissues. Every cell in the body leaves a record of its …
Nanomedicine—challenge and perspectives
…, TA Luger, B Godin, M Ferrari… - Angewandte Chemie …, 2009 - Wiley Online Library
The application of nanotechnology concepts to medicine joins two large cross‐disciplinary
fields with an unprecedented societal and economical potential arising from the natural …
fields with an unprecedented societal and economical potential arising from the natural …
Seven challenges for nanomedicine
…, JH Sakamoto, R Canady, M Ferrari - Nature nanotechnology, 2008 - nature.com
Nanomedicine offers new opportunities to fight diseases but a global effort is needed to
safely translate laboratory innovation to the clinic. Seven priority areas have been identified …
safely translate laboratory innovation to the clinic. Seven priority areas have been identified …
Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions
…, IK Yazdi, MV Enzo, L Isenhart, M Ferrari… - Nature …, 2013 - nature.com
The therapeutic efficacy of systemic drug-delivery vehicles depends on their ability to evade
the immune system, cross the biological barriers of the body and localize at target tissues. …
the immune system, cross the biological barriers of the body and localize at target tissues. …
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway
…, S Adoro, B Hu, M Song, C Tan, MD Landis, M Ferrari… - Nature, 2014 - nature.com
Cancer cells induce a set of adaptive response pathways to survive in the face of stressors
due to inadequate vascularization 1 . One such adaptive pathway is the unfolded protein (…
due to inadequate vascularization 1 . One such adaptive pathway is the unfolded protein (…
[HTML][HTML] Intravascular delivery of particulate systems: does geometry really matter?
P Decuzzi, R Pasqualini, W Arap, M Ferrari - Pharmaceutical research, 2009 - Springer
In cancer therapy and imaging, the systemic passive delivery of particulate systems has relied
on the enhanced permeability and retention (EPR) effect: sufficiently small particles can …
on the enhanced permeability and retention (EPR) effect: sufficiently small particles can …