Cancer nanotechnology: opportunities and challenges

M Ferrari - Nature reviews cancer, 2005 - nature.com
Nanotechnology is a multidisciplinary field, which covers a vast and diverse array of devices
derived from engineering, biology, physics and chemistry. These devices include …

Principles of nanoparticle design for overcoming biological barriers to drug delivery

E Blanco, H Shen, M Ferrari - Nature biotechnology, 2015 - nature.com
Biological barriers to drug transport prevent successful accumulation of nanotherapeutics
specifically at diseased sites, limiting efficacious responses in disease processes ranging from …

Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications

…, P Decuzzi, JM Tour, F Robertson, M Ferrari - Nature …, 2008 - nature.com
Many nanosized particulate systems are being developed as intravascular carriers to increase
the levels of therapeutic agents delivered to targets, with the fewest side effects 1 , 2 . The …

Clinical cancer nanomedicine

J Wolfram, M Ferrari - Nano today, 2019 - Elsevier
Nanotechnology offers new solutions for the development of cancer therapeutics that display
improved efficacy and safety. Although several nanotherapeutics have received clinical …

[HTML][HTML] Clinical proteomics: written in blood

LA Liotta, M Ferrari, E Petricoin - Nature, 2003 - nature.com
The blood contains a treasure trove of previously unstudied biomarkers that could reflect the
ongoing physiologic state of all tissues. Every cell in the body leaves a record of its …

Nanomedicine—challenge and perspectives

…, TA Luger, B Godin, M Ferrari… - Angewandte Chemie …, 2009 - Wiley Online Library
The application of nanotechnology concepts to medicine joins two large cross‐disciplinary
fields with an unprecedented societal and economical potential arising from the natural …

Seven challenges for nanomedicine

…, JH Sakamoto, R Canady, M Ferrari - Nature nanotechnology, 2008 - nature.com
Nanomedicine offers new opportunities to fight diseases but a global effort is needed to
safely translate laboratory innovation to the clinic. Seven priority areas have been identified …

Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions

…, IK Yazdi, MV Enzo, L Isenhart, M Ferrari… - Nature …, 2013 - nature.com
The therapeutic efficacy of systemic drug-delivery vehicles depends on their ability to evade
the immune system, cross the biological barriers of the body and localize at target tissues. …

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

…, S Adoro, B Hu, M Song, C Tan, MD Landis, M Ferrari… - Nature, 2014 - nature.com
Cancer cells induce a set of adaptive response pathways to survive in the face of stressors
due to inadequate vascularization 1 . One such adaptive pathway is the unfolded protein (…

[HTML][HTML] Intravascular delivery of particulate systems: does geometry really matter?

P Decuzzi, R Pasqualini, W Arap, M Ferrari - Pharmaceutical research, 2009 - Springer
In cancer therapy and imaging, the systemic passive delivery of particulate systems has relied
on the enhanced permeability and retention (EPR) effect: sufficiently small particles can …