Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma

…, T Staniscia, X Chen, F Dombrowski, M Evert - Gastroenterology, 2011 - Elsevier
BACKGROUND & AIMS: De novo lipogenesis is believed to be involved in oncogenesis.
We investigated the role of aberrant lipid biosynthesis in the pathogenesis of human …

[HTML][HTML] Cholangiocarcinomas can originate from hepatocytes in mice

…, GJ Gores, F Dombrowski, M Evert… - The Journal of …, 2012 - Am Soc Clin Investig
Intrahepatic cholangiocarcinomas (ICCs) are primary liver tumors with a poor prognosis. The
development of effective therapies has been hampered by a limited understanding of the …

Anatomical, histomorphological and molecular classification of cholangiocarcinoma

T Kendall, J Verheij, E Gaudio, M Evert… - Liver …, 2019 - Wiley Online Library
Cholangiocarcinoma constitutes a heterogeneous group of malignancies that can emerge at
any point of the biliary tree. Cholangiocarcinoma is classified into intrahepatic, perihilar and …

[PDF][PDF] p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer

DF Tschaharganeh, W Xue, DF Calvisi, M Evert… - Cell, 2014 - cell.com
The p53 tumor suppressor coordinates a series of antiproliferative responses that restrict the
expansion of malignant cells, and as a consequence, p53 is lost or mutated in the majority …

European Association of Urology (EAU) prognostic factor risk groups for non–muscle-invasive bladder cancer (NMIBC) incorporating the WHO 2004/2016 and WHO …

…, L Molinaro, CA Hulsbergen-van de Kaa, M Evert… - European urology, 2021 - Elsevier
Background The European Association of Urology (EAU) prognostic factor risk groups for
non–muscle-invasive bladder cancer (NMIBC) are used to provide recommendations for …

Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma

…, N Gretz, C Sticht, ML Tomasi, S Delogu, M Evert… - Gastroenterology, 2013 - Elsevier
BACKGROUND & AIMS: Cancer cells often lose contact inhibition to undergo anchorage-independent
proliferation and become resistant to apoptosis by inactivating the Hippo …

Activation of β-catenin and Yap1 in human hepatoblastoma and induction of hepatocarcinogenesis in mice

…, S Ribback, F Dombrowski, M Evert… - Gastroenterology, 2014 - Elsevier
Background & Aims Aberrant activation of β-catenin and Yes-associated protein 1 (Yap1)
signaling pathways have been associated with the development of multiple tumor types. Yap …

Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer

…, CO Behn, CD Heidecke, H Friess, M Büchler, M Evert… - Gut, 2012 - gut.bmj.com
Objective Pancreatic cancer is characterised by invasive tumour spread and early metastasis
formation. During epithelial–mesenchymal transition, loss of the cell adhesion molecule E-…

[HTML][HTML] Tissue Tolerable Plasma (TTP) induces apoptosis in pancreatic cancer cells in vitro and in vivo

LI Partecke, K Evert, J Haugk, F Doering, L Normann… - BMC cancer, 2012 - Springer
Background The rate of microscopic incomplete resections of gastrointestinal cancers
including pancreatic cancer has not changed considerably over the past years. Future intra-…

Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models

…, S Krueger, Z El‐Hajj, A Diestel, M Evert… - Journal of cellular …, 2008 - Wiley Online Library
We have shown that thymoquinone (TQ) is a potent antitumor agent in human colorectal
cancer cells. In this study, we evaluated TQ's therapeutic potential in two different mice colon …