3, 5-Dibenzoyl-1, 4-dihydropyridines: synthesis and MDR reversal in tumor cells

M Kawase, A Shah, H Gaveriya, N Motohashi… - Bioorganic & medicinal …, 2002 - Elsevier
Fifteen 4-phenyl-3,5-dibenzoyl-1,4-dihydropyridines (BzDHPs) (1–15) substituted at the 4-phenyl
ring were synthesized and compared to their cytotoxic activity and multidrug resistance …

Urease inhibitory activity of simple α, β-unsaturated ketones

T Tanaka, M Kawase, S Tani - Life sciences, 2003 - Elsevier
A variety of α,β-unsaturated ketones were evaluated for their effect on the jack bean urease.
Of 35 compounds tested, 2-cyclohepten-1-one (1), 2-cyclohexen-1-one (2), 2-cyclopenten-1-…

Electrophilic aromatic substitution with N-methoxy-N-acylnitrenium ions generated from N-chloro-N-methoxy amides: Syntheses of nitrogen heterocyclic compounds …

M Kawase, T Kitamura, Y Kikugawa - The Journal of Organic …, 1989 - ACS Publications
IV-Methoxy-N-acylnitrenium ions (II), generated by treatment of iV-chloro-iV-methoxyamides
with silver carbonate in trifluoroacetic acid, react with arenes to give iV-aryl-iV-…

α-Hydroxyketones as inhibitors of urease

T Tanaka, M Kawase, S Tani - Bioorganic & medicinal chemistry, 2004 - Elsevier
A variety of α-hydroxyketones (1–13) and α-diketones (14–20) were evaluated for their effect
on the jack bean urease. Of 13 α-hydroxyketones (1–13) tested, 2,2′-thenoin (10) (IC 50 =…

Cancer prevention and therapy with kiwifruit in Chinese folklore medicine: a study of kiwifruit extracts

N Motohashi, Y Shirataki, M Kawase, S Tani… - Journal of …, 2002 - Elsevier
Kiwi gold fruits were extracted successively with hexane, acetone, methanol and 70% methanol,
and further fractionated by silica gel and ODS column chromatographies for the assays …

Biological activity of persimmon (Diospyros kaki) peel extracts

M Kawase, N Motohashi, K Satoh… - Phytotherapy …, 2003 - Wiley Online Library
(HSC-2) and human submandibular gland tumor (HSG) cells was found in the acetone fractions
(A4 and A5) with IC50 ranging from 21 to 59 µg/mL. However, the cytotoxic activity was …

Antitumor potential and possible targets of phenothiazine-related compounds

N Motohashi, M Kawase, S Saito… - Current drug …, 2000 - ingentaconnect.com
Phenothiazines and its related compounds have shown diverse biological activities
including psychotropic, anticancer and other pharmacological activities. Recent studies have …

Biological activity of barbados cherry (acerola fruits, fruit of Malpighia emarginata DC) extracts and fractions

…, H Fukushima, T Yamada, M Kawase… - … Journal Devoted to …, 2004 - Wiley Online Library
Helicobacter pylori, two representative Candida species, and human immunodeficiency
virus (HIV). H3, H4 and HE3, which displayed higher tumor-specific cytotoxicity also showed …

Cytotoxic potential of phenothiazines

N Motohashi, M Kawase, K Satoh… - Current Drug …, 2006 - ingentaconnect.com
Phenothiazines, a kind of sulfur-containing tricyclic compounds, have diverse biological
activities including tranquilizer, antibacterial, antitumor and antihelmintic activities due to the …

Cytotoxic 3, 5-bis (benzylidene) piperidin-4-ones and N-acyl analogs displaying selective toxicity for malignant cells

HN Pati, U Das, JW Quail, M Kawase… - European journal of …, 2008 - Elsevier
A series of 3,5-bis(benzylidene)piperidin-4-ones 1, 1-acryloyl-3,5-bis(benzylidene)piperidin-4-ones
2 and adducts of 2 with sodium 2-mercaptoethanesulfonate (mesna), namely series …