Expression of estrogen receptor (ER), progesterone receptor (PR), and the human epidermal
growth factor receptor 2 (HER2) can subdivide breast carcinomas into clinically meaningful …

Purpose: This study examined acceptability of two biobank consent models and evaluated
the impact of beliefs about privacy and genetic safeguards on acceptance. Methods: US …

Purpose Minorities are often underrepresented in clinical cancer research yet the frequency
of reporting of race in genomic sequencing studies of cancer is unknown. This scoping …

Introduction PTEN is a tumor suppressor gene that inhibits cell proliferation by inhibiting the
phosphoinositide 3-kinase (PI3 K) signaling pathway. The significance of PTEN mutations …

Expanded implementation of genetic sequencing has precipitously increased the discovery
of germline and somatic variants. The direct benefit of identifying variants in actionable …

Background Inter-individual variation in DNA repair capacity is thought to modulate breast
cancer risk. The phenotypic mutagen sensitivity assay (MSA) measures DNA strand breaks in …

Precision medicine tools are currently making their way into the clinic and being utilized to
diagnose, prognose, and individualize cancer care. The multi‐gene expression‐based assay, …

Background/Aims: Breast cancer (BCa) prognostication is a vital element for providing effective
treatment for patients with BCa. Studies suggest that ethnicity plays a greater role in the …

Results of studies for the association of BRCA1 genotypes and haplotypes with sporadic
breast cancer have been inconsistent. Therefore, a candidate single nucleotide polymorphism (…

The objective of this study was to identify predictors of self-reported family health history of
breast cancer in an ethnically diverse population of women participating in a breast cancer …