A novel enzyme enantio-selectively synthesizes (R) salsolinol, a precursor of a dopaminergic neurotoxin, N-methyl (R) salsolinol

M Naoi, W Maruyama, P Dostert, K Kohda, T Kaiya - Neuroscience letters, 1996 - Elsevier
In the human brain, only (R)enantiomer of 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline
((R)salsolinol) and N-methyl-salsolinol, a dopaminergic neurotoxin, were detected, …

Thiol-based SAHA analogues as potent histone deacetylase inhibitors

…, A Matsuura, A Kohara, S Ninomiya, K Kohda… - Bioorganic & medicinal …, 2004 - Elsevier
In order to find novel nonhydroxamate histone deacetylase (HDAC) inhibitors, a series of
thiol-based compounds modeled after suberoylanilide hydroxamic acid (SAHA) was …

An Endogenous Dopaminergic Neurotoxin, N‐Methyl‐(R)‐Salsolinol, Induces DNA Damage in Human Dopaminergic Neuroblastoma SH‐SY5Y Cells

…, Y Hashizume, T Takahashi, K Kohda… - Journal of …, 1997 - Wiley Online Library
Recently, an endogenous neurotoxin, 1(R),2(N)‐dimethyl‐6,7‐dihydroxy‐1,2,3,4‐tetrahydroisoquinoline
[N‐methyl‐(R)‐salsolinol], was found to elicit parkinsonism in rats with selective …

Novel histone deacetylase inhibitors: design, synthesis, enzyme inhibition, and binding mode study of SAHA-based non-hydroxamates

…, A Matsuura, A Kohara, S Ninomiya, K Kohda… - Bioorganic & Medicinal …, 2003 - Elsevier
In order to find novel non-hydroxamate histone deacetylase (HDAC) inhibitors, a series of
compounds modeled after suberoylanilide hydroxamic acid (SAHA) were designed and …

Formation of 8-hydroxyguanine residues in cellular DNA exposed to the carcinogen 4-nitroquinoline 1-oxide

K Kohda, M Tada, H Kasai, S Nishimura… - … and biophysical research …, 1986 - Elsevier
8-Hydroxyguanine (8-OH-Gua) residues were formed in DNA of Ehrlich ascites cells exposed
to the carcinogen 4-nitro-quinoline 1-oxide. Formation of 8-OH-Gua was confirmed by …

Enhanced cytotoxicity of some triterpenes toward leukemia L1210 cells cultured in low pH media: possibility of a new mode of cell killing

Y Noda, T Kaiya, K Kohda… - Chemical and …, 1997 - jstage.jst.go.jp
Several triterpenes were tested for cytotoxieity by our contrived primary screening method
using resting or dormant leukemia L1210 cells after 3d-preculture without medium change. …

Miscoding Potential of the N2-Ethyl-2'-deoxyguanosine DNA Adduct by the Exonuclease-Free Klenow Fragment of Escherichia coli DNA Polymerase I

…, TW Fang, N Suzuki, J Kobayashi, K Kohda… - Biochemistry, 2001 - ACS Publications
Acetaldehyde, a major metabolite of ethanol, reacts with dG residues in DNA, resulting in
the formation of the N 2 -ethyl-2‘-deoxyguanosine (N 2 -Et-dG) adduct. This adduct has been …

Comparison of chemically induced DNA breakage in cellular and subcellular systems using the comet assay

T Kasamatsu, K Kohda, Y Kawazoe - Mutation Research/Genetic …, 1996 - Elsevier
The alkaline comet assay, employing a single cell gel electrophoresis, is a rapid, simple and
sensitive technique for visualizing and measuring DNA damage leading to strand breakage …

Separation and identification of N4-(guanosin-7-yl)-4-aminoquinoline 1-oxide, a novel nucleic acid adduct of carcinogen 4-nitroquinoline 1-oxide

K Kohda, Y Kawazoe, Y Minoura, M Tada - Carcinogenesis, 1991 - academic.oup.com
A novel nucleic acid adduct of the carcinogen 4-nitroquinoline 1-oxide, N 4 -(guanosin-7-yl)-4-aminoquinoline
1-oxide, was separated and identified after RNA was treated with …

Design, synthesis, and biological activity of novel PPARγ ligands based on rosiglitazone and 15d-PGJ2

…, M Imagawa, H Nakagawa, K Kohda… - Bioorganic & medicinal …, 2005 - Elsevier
To develop novel PPARγ ligands, we synthesized thirteen 3-{4-(2-aminoethoxy)phenyl}propanoic
acid derivatives, which are designed based on the structures of rosiglitazone and 15d-…