The enzyme cyclooxygenase-2 (COX-2) is abundantly expressed in colon cancer cells and
plays a key role in colon tumorigenesis. Compounds inhibiting COX-2 transcriptional activity …

Water-soluble ingredients of the herbal medicine sho-saiko-to dose-dependently inhibited
the proliferation of a human hepatocellular carcinoma cell line (KIM-1) and a …

Background—The presence of apoptotic myocytes has been reported in human hearts with
dilated cardiomyopathy (DCM) on the basis of a positive finding of DNA in situ nick end-…

Cyclooxygenase-2 (COX-2) is abundantly expressed in colon cancer cells. It has been reported
that inhibition of COX-2 enzyme activity is shown to prevent colon carcinogenesis. Thus, …

We previously reported that gallic acid (3, 4, 5-trihydroxybenzoic acid), a naturally occurring
plant phenol, can induce apoptosis in four kinds of human lung cancer cell lines in vitro. The …

Cyclooxygenase‐2 (COX‐2) plays an important role in carcinogenesis. Investigation of the
suppressive action of twelve flavonoids of different chemical classes on the transcriptional …

β-Catenin is a key regulator of the cadherin-mediated cell-cell adhesion system and an
important element in the Wnt signal transduction pathway. Stabilization and accumulation of …

Activator protein 1 (AP-1) is a transcription factor which plays a critical role in inflammation
and carcinogenesis. The present study was conducted to investigate the effect of berberine, …

Background & Aims: We showed previously that a Kampo (Chinese/Japanese herbal) medicine,
Inchin-ko-to (ICKT), inhibits hepatocyte apoptosis induced by transforming growth factor …

The apoptosis-inducing effect of gallic acid (3, 4, 5-trihydroxy-benzoic acid) was investigated
in four human lung cancer cell lines, SBC-3 (small cell carcinoma), EBC-1 (squamous cell …